Gene Symbol | FABP6 |
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Entrez Gene | 2172 |
Alt Symbol | I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP |
Species | Human |
Gene Type | protein-coding |
Description | fatty acid binding protein 6, ileal |
Other Description | GT|gastrotropin|ileal bile acid binding protein|ileal lipid-binding protein|illeal lipid-binding protein|intestinal 15 kDa protein |
Swissprots | P51161 Q8TBI3 Q07DR7 Q9UGI7 |
Accessions | CAB65728 CAC81780 EAW61563 EAW61564 EAW61565 EAW61566 P51161 AI208231 BC022489 AAH22489 DQ132786 ABA12611 HQ448339 ADQ32819 U19869 AAB82751 X90908 CAA62415 XM_006714830 XP_006714893 XM_011534463 XP_011532765 NM_001040442 NP_001035532 NM_001130958 NP_001124430 NM_001445 NP_001436 |
Function | Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis. {ECO:0000269|PubMed:17909007}. |
Subcellular Location | Isoform 1: Cytoplasm. |
Tissue Specificity | Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. {ECO:0000269|PubMed:17909007}. |
Top Pathways | PPAR signaling pathway |
ILBP CRISPR/Cas9 KO Plasmid (h) - sc-405418 from Santa Cruz Biotechnology
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ILBP HDR Plasmid (h) - sc-405418-HDR from Santa Cruz Biotechnology
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ILBP Double Nickase Plasmid (h) - sc-405418-NIC from Santa Cruz Biotechnology
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ILBP Double Nickase Plasmid (h2) - sc-405418-NIC-2 from Santa Cruz Biotechnology
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ILBP CRISPR Activation Plasmid (h) - sc-405418-ACT from Santa Cruz Biotechnology
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ILBP CRISPR Activation Plasmid (h2) - sc-405418-ACT-2 from Santa Cruz Biotechnology
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ILBP Lentiviral Activation Particles (h) - sc-405418-LAC from Santa Cruz Biotechnology
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ILBP Lentiviral Activation Particles (h2) - sc-405418-LAC-2 from Santa Cruz Biotechnology
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ILBP siRNA (h) - sc-41241 from Santa Cruz Biotechnology
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ILBP shRNA Plasmid (h) - sc-41241-SH from Santa Cruz Biotechnology
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ILBP shRNA (h) Lentiviral Particles - sc-41241-V from Santa Cruz Biotechnology
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FABP6 RNAi - H00002172-R01 from Novus Biologicals
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MISSION® esiRNA - EHU100931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8086 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8086 from Sigma-Aldrich
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FABP6 siRNA (Human) - CRH1512 from Cohesion Biosciences
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FABP6 - MBS8200163 from MyBioSource
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shRNA set against Human FABP6 (NM_001445.2) - SHH288661 from Creative biogene
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shRNA set against Human FABP6(NM_001040442.1) - SHH044147 from Creative biogene
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shRNA set against Human FABP6(NM_001445.2) - SHH044183 from Creative biogene
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Human FABP6 siRNA - orb262014 from Biorbyt
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FABP6 shRNA Plasmid (Human) - CHH1512 from Cohesion Biosciences
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FABP6 miRNA 3'UTR clone - MiUTR1H-03372 from Creative biogene
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FABP6 miRNA 3'UTR clone - MiUTR1H-03373 from Creative biogene
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FABP6 miRNA 3'UTR clone - MiUTR3H-03366 from Creative biogene
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