| Gene Symbol |
CDCA5
|
| Entrez Gene |
113130
|
| Alt Symbol |
SORORIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell division cycle associated 5
|
| Other Description |
cell division cycle-associated protein 5|p35|sororin
|
| Swissprots |
A8K625 Q96FF9
|
| Accessions |
EAW74342 EAW74343 Q96FF9 AK093670 BAG52747 AK291490 BAF84179 AL832526 BC011000 AAH11000 CN332525 DQ893251 ABM84177 DQ896580 ABM87579 XM_005273733 XP_005273790 XM_005273734 XP_005273791 XM_011544743 XP_011543045 XM_011544744 XP_011543046 XM_011544745 XP_011543047 XM_011544746 XP_011543048 XM_011544747 XP_011543049 XM_011544748 XP_011543050 XM_011544749 XP_011543051 XR_949779 XR_949781 NM_080668 NP_542399
|
| Function |
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15837422}. Chromosome {ECO:0000269|PubMed:15837422}. Cytoplasm {ECO:0000269|PubMed:15837422}. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
|
| Top Pathways |
MicroRNAs in cancer
|
![Western Blot: CDCA5 Overexpression Lysate (Adult Normal) [NBL1-09019] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDCA5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13760_CDCA5%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09019-img0002.jpg)