Gene Symbol | CDCA5 |
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Entrez Gene | 113130 |
Alt Symbol | SORORIN |
Species | Human |
Gene Type | protein-coding |
Description | cell division cycle associated 5 |
Other Description | cell division cycle-associated protein 5|p35|sororin |
Swissprots | A8K625 Q96FF9 |
Accessions | EAW74342 EAW74343 Q96FF9 AK093670 BAG52747 AK291490 BAF84179 AL832526 BC011000 AAH11000 CN332525 DQ893251 ABM84177 DQ896580 ABM87579 XM_005273733 XP_005273790 XM_005273734 XP_005273791 XM_011544743 XP_011543045 XM_011544744 XP_011543046 XM_011544745 XP_011543047 XM_011544746 XP_011543048 XM_011544747 XP_011543049 XM_011544748 XP_011543050 XM_011544749 XP_011543051 XR_949779 XR_949781 NM_080668 NP_542399 |
Function | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15837422}. Chromosome {ECO:0000269|PubMed:15837422}. Cytoplasm {ECO:0000269|PubMed:15837422}. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown. |
Top Pathways | MicroRNAs in cancer |
Sororin (B-9) - sc-365319 from Santa Cruz Biotechnology
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Sororin (D-11) - sc-390900 from Santa Cruz Biotechnology
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Sororin (M-190) - sc-67248 from Santa Cruz Biotechnology
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Sororin (FL-252) - sc-67247 from Santa Cruz Biotechnology
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Sororin (S-17) - sc-49323 from Santa Cruz Biotechnology
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Sororin (I-16) - sc-49322 from Santa Cruz Biotechnology
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Anti-CDCA5 antibody - ab168217 from Abcam
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Anti-CDCA5 antibody - ab104780 from Abcam
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Anti-CDCA5 antibody - ab106321 from Abcam
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Anti-CDCA5 antibody - ab56054 from Abcam
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Anti-CDCA5 antibody [EPR16331] - C-terminal - ab192237 from Abcam
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Anti-CDCA5 / Sororin Antibody (aa110-159) IHC-plus™ - LS-B9756 from LifeSpan Bioscience
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Anti-CDCA5 / Sororin Antibody - LS-C306870 from LifeSpan Bioscience
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Anti-CDCA5 / Sororin Antibody (N-Terminus) - LS-C46946 from LifeSpan Bioscience
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Anti-CDCA5 / Sororin Antibody (aa143-192) - LS-C116783 from LifeSpan Bioscience
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CDCA5 Antibody - NBP1-89530 from Novus Biologicals
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CDCA5 Antibody - H00113130-B01P from Novus Biologicals
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CDCA5 Antibody - NBP1-55143 from Novus Biologicals
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p35 Antibody - NBP2-21650 from Novus Biologicals
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CDCA5 Antibody - NBP1-55144 from Novus Biologicals
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Rabbit Anti-p35/CDK5P1 Polyclonal Antibody - bs-11611R from Bioss
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Sororin Polyclonal Antibody - bs-7717R from Bioss
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Rabbit Anti-p35/CDK5P1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11611R-A350 from Bioss
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Rabbit Anti-p35/CDK5P1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11611R-A488 from Bioss
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Rabbit Anti-p35/CDK5P1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11611R-A555 from Bioss
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