Gene Symbol | ISCA1 |
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Entrez Gene | 81689 |
Alt Symbol | HBLD2, ISA1, hIscA |
Species | Human |
Gene Type | protein-coding |
Description | iron-sulfur cluster assembly 1 |
Other Description | HESB like domain containing 2|HESB-like domain-containing protein 2|iron sulfur assembly protein IscA|iron-sulfur assembly protein IscA|iron-sulfur cluster assembly 1 homolog, mitochondrial |
Swissprots | Q9BZR2 B4DJI5 Q8ND75 B3KP34 Q9BUE6 |
Accessions | EAW62712 EAW62713 Q9BUE6 AA745613 AF038186 AF284752 AAG59854 AI436792 AK055643 BAG51546 AK225937 AK296093 BAG58847 AL834356 CAD39021 AY015642 AAG40950 BC002675 AAH02675 BC053900 BC071621 AAH71621 BG772866 NM_030940 NP_112202 |
Function | Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. {ECO:0000269|PubMed:15262227, ECO:0000269|PubMed:22323289}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:15262227, ECO:0000269|PubMed:22323289}. |
Tissue Specificity | Detected in cerebellum, kidney and heart. {ECO:0000269|PubMed:15262227}. |
ISCA1 CRISPR/Cas9 KO Plasmid (h) - sc-408972 from Santa Cruz Biotechnology
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ISCA1 HDR Plasmid (h) - sc-408972-HDR from Santa Cruz Biotechnology
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ISCA1 Double Nickase Plasmid (h) - sc-408972-NIC from Santa Cruz Biotechnology
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ISCA1 Double Nickase Plasmid (h2) - sc-408972-NIC-2 from Santa Cruz Biotechnology
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ISCA1 CRISPR Activation Plasmid (h) - sc-408972-ACT from Santa Cruz Biotechnology
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ISCA1 CRISPR Activation Plasmid (h2) - sc-408972-ACT-2 from Santa Cruz Biotechnology
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ISCA1 Lentiviral Activation Particles (h) - sc-408972-LAC from Santa Cruz Biotechnology
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ISCA1 Lentiviral Activation Particles (h2) - sc-408972-LAC-2 from Santa Cruz Biotechnology
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ISCA1 siRNA (h) - sc-92646 from Santa Cruz Biotechnology
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ISCA1 shRNA Plasmid (h) - sc-92646-SH from Santa Cruz Biotechnology
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ISCA1 shRNA (h) Lentiviral Particles - sc-92646-V from Santa Cruz Biotechnology
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HBLD2 RNAi - H00081689-R01 from Novus Biologicals
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MISSION® esiRNA - EHU043211 from Sigma-Aldrich
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MISSION® esiRNA - EHU107421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10783 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10783 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09454 from Sigma-Aldrich
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ISCA1 siRNA (Human) - CRJ3041 from Cohesion Biosciences
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ISCA1 - MBS8222478 from MyBioSource
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shRNA set against Human ISCA1 (NM_030940.3) - SHH320869 from Creative biogene
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shRNA set against Human ISCA1(NM_030940.3) - SHL174212 from Creative biogene
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Human ISCA1 siRNA - orb273542 from Biorbyt
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ISCA1 shRNA Plasmid (Human) - CHJ3041 from Cohesion Biosciences
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ISCA1 miRNA 3'UTR clone - MiUTR1H-05005 from Creative biogene
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