| Gene Symbol | COPA |
|---|---|
| Entrez Gene | 1314 |
| Alt Symbol | HEP-COP |
| Species | Human |
| Gene Type | protein-coding |
| Description | coatomer protein complex, subunit alpha |
| Other Description | HEPCOP|alpha coat protein|alpha-COP|alpha-coat protein|coatomer subunit alpha|proxenin|xenin |
| Swissprots | P53621 Q8IXZ9 Q5T201 |
| Accessions | CAH56812 EAW52723 EAW52724 EAW52725 P53621 AK129830 AK307953 BC037941 BC038447 AAH38447 DC308331 U24105 AAB70879 NM_001098398 NP_001091868 NM_004371 NP_004362 |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}. |
| Tissue Specificity | Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells. |