COPA

Gene Symbol	COPA
Entrez Gene	1314
Alt Symbol	HEP-COP
Species	Human
Gene Type	protein-coding
Description	coatomer protein complex, subunit alpha
Other Description	HEPCOP|alpha coat protein|alpha-COP|alpha-coat protein|coatomer subunit alpha|proxenin|xenin
Swissprots	P53621 Q8IXZ9 Q5T201
Accessions	CAH56812 EAW52723 EAW52724 EAW52725 P53621 AK129830 AK307953 BC037941 BC038447 AAH38447 DC308331 U24105 AAB70879 NM_001098398 NP_001091868 NM_004371 NP_004362
Function	The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Tissue Specificity	Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

COPA (H-3) - sc-398099 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

COPA (H-300) - sc-366161 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

COPA (T-19) - sc-21917 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

COPA (D-24) - sc-133474 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Rabbit Clonality Polyclonal

Anti-alpha COP I antibody [EPR14273(B)] - ab181224 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14273(B)

Anti-COPA / Xenin Antibody (aa396-445) - LS-C111343 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-COPA / Xenin Antibody (aa22-71) - LS-C81674 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-COPA / Xenin Antibody (Internal) - LS-C186468 from LifeSpan Bioscience Host Goat Clonality Polyclonal

Anti-COPA / Xenin Antibody (aa1-19) IHC-plus™ - LS-B2566 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

alpha COP I Antibody - NBP1-89705 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

alpha COP I Antibody - NBP1-59298 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

alpha COP I Antibody - NBP1-59297 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

alpha COP I Antibody - NB120-2913 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

alpha COP I Antibody - H00001314-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody - bs-12464R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12464R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12464R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12464R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12464R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, Cy3 Conjugated - bs-12464R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, Cy5 Conjugated - bs-12464R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, Cy5.5 Conjugated - bs-12464R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, Cy7 Conjugated - bs-12464R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, FITC Conjugated - bs-12464R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

COPA/alpha COP I Polyclonal Antibody, Biotin Conjugated - bs-12464R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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