PPP2CB
| Gene Symbol | PPP2CB |
|---|---|
| Entrez Gene | 5516 |
| Alt Symbol | PP2Abeta, PP2CB |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 2, catalytic subunit, beta isozyme |
| Other Description | PP2A-beta|protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform|protein phosphatase 2, catalytic subunit, beta isoform|protein phosphatase 2A catalytic subunit, beta isoform|protein phosphatase type 2A catalytic subunit|serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform|serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
| Swissprots | Q6FHK5 P11082 D3DSV4 P62714 |
| Accessions | AAA36467 EAW63433 EAW63434 EAW63435 EAW63436 P62714 AF444006 AAL35904 AK091875 BAG52434 BC012022 AAH12022 BG716837 BT019526 AAV38333 CA419001 CF594136 CR541747 CAG46547 J03805 AAB38020 X12656 CAA31183 NM_001009552 NP_001009552 NM_004156 |
| Function | PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. {ECO:0000269|PubMed:2555176}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. |
| Top Pathways | Sphingolipid signaling pathway, Adrenergic signaling in cardiomyocytes, AMPK signaling pathway, Hippo signaling pathway, TGF-beta signaling pathway |
PP2A-Cβ siRNA (h) - sc-36301 from Santa Cruz Biotechnology
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PP2A-Cβ shRNA Plasmid (h) - sc-36301-SH from Santa Cruz Biotechnology
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PP2A-Cβ shRNA (h) Lentiviral Particles - sc-36301-V from Santa Cruz Biotechnology
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PP2A-Cβ siRNA (h2) - sc-39175 from Santa Cruz Biotechnology
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PP2A-Cβ shRNA Plasmid (h2) - sc-39175-SH from Santa Cruz Biotechnology
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PP2A-Cβ shRNA (h2) Lentiviral Particles - sc-39175-V from Santa Cruz Biotechnology
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PPP2CB RNAi - H00005516-R04 from Novus Biologicals
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PPP2CB RNAi - H00005516-R03 from Novus Biologicals
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MISSION® esiRNA - EHU006921 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0605 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0606 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1034 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0604 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1033 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17288 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17288 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04708 from Sigma-Aldrich
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PPP2CB siRNA (Human) - CRH3696 from Cohesion Biosciences
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shRNA set against Human PPP2CB (NM_001009552.1) - SHH381348 from Creative biogene
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shRNA set against Human PPP2CB(NM_001009552.1) - SHR134266 from Creative biogene
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PPP2CB shRNA Plasmid (Human) - CHH3696 from Cohesion Biosciences
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PPP2CB miRNA 3'UTR clone - MiUTR1H-08189 from Creative biogene
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