Gene Symbol | XRCC1 |
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Entrez Gene | 7515 |
Alt Symbol | RCC |
Species | Human |
Gene Type | protein-coding |
Description | X-ray repair complementing defective repair in Chinese hamster cells 1 |
Other Description | DNA repair protein XRCC1|X-ray repair cross-complementing protein 1 |
Swissprots | Q9HCB1 Q6IBS4 P18887 |
Accessions | AAG09061 AAM34791 AGB76026 AGI15891 AGI15892 AGI15893 AHC92541 EAW57201 EAW57202 EAW57203 P18887 AB208781 BAD92018 AK293542 BAG57023 AK300163 BAG61945 AK315332 BAG37732 BC023593 AAH23593 BP349667 CR456728 CAG33009 M36089 AAA63270 NM_006297 NP_006288 |
Function | Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17353262}. Note=Accumulates at sites of DNA damage. |
Top Pathways | Base excision repair |
XRCC1 CRISPR/Cas9 KO Plasmid (h) - sc-401784 from Santa Cruz Biotechnology
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XRCC1 HDR Plasmid (h) - sc-401784-HDR from Santa Cruz Biotechnology
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XRCC1 Double Nickase Plasmid (h) - sc-401784-NIC from Santa Cruz Biotechnology
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XRCC1 Double Nickase Plasmid (h2) - sc-401784-NIC-2 from Santa Cruz Biotechnology
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XRCC1 CRISPR Activation Plasmid (h) - sc-401784-ACT from Santa Cruz Biotechnology
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XRCC1 CRISPR Activation Plasmid (h2) - sc-401784-ACT-2 from Santa Cruz Biotechnology
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XRCC1 Lentiviral Activation Particles (h) - sc-401784-LAC from Santa Cruz Biotechnology
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XRCC1 Lentiviral Activation Particles (h2) - sc-401784-LAC-2 from Santa Cruz Biotechnology
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XRCC1 siRNA (h) - sc-36859 from Santa Cruz Biotechnology
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XRCC1 shRNA Plasmid (h) - sc-36859-SH from Santa Cruz Biotechnology
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XRCC1 shRNA (h) Lentiviral Particles - sc-36859-V from Santa Cruz Biotechnology
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XRCC1 RNAi - H00007515-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN2341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2341 from Sigma-Aldrich
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XRCC1 siRNA (Human) - CRH5136 from Cohesion Biosciences
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XRCC1 - MBS8230235 from MyBioSource
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shRNA set against Human XRCC1 (NM_006297.2) - SHH448084 from Creative biogene
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Human XRCC1 siRNA - orb265638 from Biorbyt
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XRCC1 shRNA Plasmid (Human) - CHH5136 from Cohesion Biosciences
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XRCC1 miRNA 3'UTR clone - MiUTR3H-02418 from Creative biogene
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