MEX3C

Gene Symbol MEX3C
Entrez Gene 51320
Alt Symbol BM-013, MEX-3C, RKHD2, RNF194
Species Human
Gene Type protein-coding
Description mex-3 RNA binding family member C
Other Description RING finger and KH domain-containing protein 2|RING finger protein 194|RNA-binding E3 ubiquitin-protein ligase MEX3C|RNA-binding protein MEX3C|ring finger and KH domain containing 2
Swissprots Q9NZE3 A1L022 Q5U5Q3
Accessions EAW62989 Q5U5Q3 AF208855 AAF64269 AK096190 BAG53227 AL833519 AW079942 AY950679 AAY34147 BC032952 BC041122 AAH41122 BC063244 BC146416 AAI46417 BC148855 AAI48856 BC153820 AAI53821 KC456343 AGI99528 KC456344 AGI99529 NM_016626 NP_057710
Function E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17267406}. Nucleus {ECO:0000269|PubMed:17267406}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
Tissue Specificity Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine. {ECO:0000269|PubMed:17267406, ECO:0000269|PubMed:22863774}.

Mex3c (D-10) - sc-398440 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mex3c (D-10): sc-398440. Western blot analysis of Mex3c expression in SK-BR-3 (A), Caki-1 (B), HeLa (C), LNCaP (D) and Caco-2 (E) whole cell lysates.

Mex3c (D-17) - sc-85057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Mex3c (D-17): sc-85057. Western blot analysis of Mex3c expression in SK-BR-3 (A) and Caki-1 (B) whole cell lysates.

Mex3c (G-18) - sc-85058 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Mex3c (G-18): sc-85058. Western blot analysis of Mex3c expression in 293T whole cell lysate.

Anti-MEX3C antibody - ab79041 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-MEX3C antibody (ab79041) at 0.5 µg/mlLane 2 : Anti-MEX3C antibody (ab79041) at 1 µg/mlLane 1 : Rat heart tissue lysate Lane 2 : Rat heart tissue lysate Lysates/proteins at 15 µg per lane.

Anti-MEX3C antibody - ab167209 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-MEX3C antibody (ab167209) at 1 µg/mlLane 1 : Lysate from 293T cells transfected with MEX3CLane 2 : Non-transfected 293T cell lysate

Anti-MEX3C antibody - C-terminal - ab156374 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MEX3C antibody - C-terminal (ab156374) at 1/100 dilution + MDA-MB453 cell lysate at 35 µg

Anti-MEX3C Antibody (aa541-554) IHC-plus™ - LS-B10347 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MEX3C antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10347 concentration 5 ug/ml.

Anti-MEX3C Antibody (aa536-564, AP) - LS-C237587 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MEX3C Antibody (aa536-564, Biotin) - LS-C237591 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MEX3C Antibody (aa536-564, FITC) - LS-C237592 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MEX3C Antibody (aa536-564, APC) - LS-C237588 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MEX3C Antibody (aa536-564, PE) - LS-C237593 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MEX3C Antibody (aa536-564, Azide-free, HRP) - LS-C248806 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MEX3C Antibody (aa536-564) - LS-C322978 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MEX3C Antibody (C-Terminus) - LS-C82868 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of Rkhd2 in rat heart tissue lysate with Rkhd2 antibody at (A) 0.5 ug/ml and (B) 1 ug/ml

Anti-MEX3C Antibody (aa536-564) - LS-C157885 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MEX3C Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The MEX3C antibody detected the MEX3C protein (arrow).

MEX3C Antibody - NBP1-76341 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: MEX3C Antibody [NBP1-76341] - Rat heart tissue lysate with MEX3C antibody at (A) 0.5 ug/mL and (B) 1 ug/mL.

MEX3C Antibody - NBP1-81932 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: MEX3C Antibody [NBP1-81932] - Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.

Anti-RKHD2 antibody produced in mouse - SAB1409410 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RKHD2: <B>Cat. No. SAB1409410</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~51 kDa using MEX3C transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-RKHD2 antibody produced in rabbit - PRS4857 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-Rkhd2: <B>Cat. No. PRS4857</B> Western blot analysis of Rkhd2 in rat heart tissue lysate with Rkhd2 antibody at (A) 0.5 μg/mL and (B) 1 μg/mL.

Anti-MEX3C antibody produced in rabbit - HPA040603 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MEX3C: <B>Cat. No. HPA040603</B>: Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.

Anti-MEX3C antibody produced in goat - SAB2502068 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MEX3C<B>Cat. No. SAB2502068</B>: Immunoblotting (0.2 μg/mL) staining of Mouse Testis (+/+ is wt, trp/trp is knock-down) lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

MEX3C-Antibody-C-term - AP20253b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
MEX3C Antibody (C-term) (Cat. #AP20253b) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the MEX3C antibody detected the MEX3C protein (arrow).

MEX3C-aa541-554-Antibody-internal-region - AF3772a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3772a (0.2 µg/ml) staining of Mouse Testis (+/+ is wt, trp/trp is knock-down) lysate (35 µg protein in RIPA buffer). Data obtained by Dr. B. Lu, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA. Primary incubation was 1 hour. Detected by chemiluminescence.

MEX3C Antibody - C-terminal region (OAAB15621) - OAAB15621 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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