| Gene Symbol |
MEX3C
|
| Entrez Gene |
51320
|
| Alt Symbol |
BM-013, MEX-3C, RKHD2, RNF194
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mex-3 RNA binding family member C
|
| Other Description |
RING finger and KH domain-containing protein 2|RING finger protein 194|RNA-binding E3 ubiquitin-protein ligase MEX3C|RNA-binding protein MEX3C|ring finger and KH domain containing 2
|
| Swissprots |
Q9NZE3 A1L022 Q5U5Q3
|
| Accessions |
EAW62989 Q5U5Q3 AF208855 AAF64269 AK096190 BAG53227 AL833519 AW079942 AY950679 AAY34147 BC032952 BC041122 AAH41122 BC063244 BC146416 AAI46417 BC148855 AAI48856 BC153820 AAI53821 KC456343 AGI99528 KC456344 AGI99529 NM_016626 NP_057710
|
| Function |
E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17267406}. Nucleus {ECO:0000269|PubMed:17267406}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
|
| Tissue Specificity |
Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine. {ECO:0000269|PubMed:17267406, ECO:0000269|PubMed:22863774}.
|