| Gene Symbol | ASGR2 |
|---|---|
| Entrez Gene | 433 |
| Alt Symbol | ASGP-R2, ASGPR2, CLEC4H2, HBXBP, HL-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | asialoglycoprotein receptor 2 |
| Other Description | C-type lectin domain family 4 member H2|HBxAg-binding protein|hepatic lectin H2 |
| Swissprots | A8MT12 D3DTN0 D3DTM9 P07307 A6NLV8 Q03969 O00448 |
| Accessions | EAW90259 EAW90260 EAW90261 EAW90262 EAW90263 EAW90264 P07307 AF529374 AAQ09608 AK303787 BAG64744 AK310123 BC017251 AAH17251 BM561839 BX483468 DC315727 DQ892652 ABM83578 DQ895891 ABM86817 M11025 AAB59519 U97197 AAB58308 X55283 CAA38997 X55284 XM_005256648 XP_005256705 XM_006721524 XP_006721587 XM_006721525 XP_006721588 XM_006721526 XP_006721589 XM_011523862 XP_011522164 XM_011523863 XP_011522165 XM_011523864 XP_011522166 XM_011523865 XP_011522167 XM_011523866 XP_011522168 NM_001181 NP_001172 NM_001201352 NP_001188281 NM_080912 NP_550434 NM_080913 NP_550435 NM_080914 NP_550436 |
| Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
| Subcellular Location | Membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
| Top Pathways | Thyroid hormone synthesis |