Gene Symbol | ASGR2 |
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Entrez Gene | 433 |
Alt Symbol | ASGP-R2, ASGPR2, CLEC4H2, HBXBP, HL-2 |
Species | Human |
Gene Type | protein-coding |
Description | asialoglycoprotein receptor 2 |
Other Description | C-type lectin domain family 4 member H2|HBxAg-binding protein|hepatic lectin H2 |
Swissprots | A8MT12 D3DTN0 D3DTM9 P07307 A6NLV8 Q03969 O00448 |
Accessions | EAW90259 EAW90260 EAW90261 EAW90262 EAW90263 EAW90264 P07307 AF529374 AAQ09608 AK303787 BAG64744 AK310123 BC017251 AAH17251 BM561839 BX483468 DC315727 DQ892652 ABM83578 DQ895891 ABM86817 M11025 AAB59519 U97197 AAB58308 X55283 CAA38997 X55284 XM_005256648 XP_005256705 XM_006721524 XP_006721587 XM_006721525 XP_006721588 XM_006721526 XP_006721589 XM_011523862 XP_011522164 XM_011523863 XP_011522165 XM_011523864 XP_011522166 XM_011523865 XP_011522167 XM_011523866 XP_011522168 NM_001181 NP_001172 NM_001201352 NP_001188281 NM_080912 NP_550434 NM_080913 NP_550435 NM_080914 NP_550436 |
Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
Top Pathways | Thyroid hormone synthesis |
ASGPR2 CRISPR/Cas9 KO Plasmid (h) - sc-417164 from Santa Cruz Biotechnology
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ASGPR2 HDR Plasmid (h) - sc-417164-HDR from Santa Cruz Biotechnology
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ASGPR2 Double Nickase Plasmid (h) - sc-417164-NIC from Santa Cruz Biotechnology
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ASGPR2 Double Nickase Plasmid (h2) - sc-417164-NIC-2 from Santa Cruz Biotechnology
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ASGPR2 CRISPR Activation Plasmid (h) - sc-417164-ACT from Santa Cruz Biotechnology
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ASGPR2 CRISPR Activation Plasmid (h2) - sc-417164-ACT-2 from Santa Cruz Biotechnology
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ASGPR2 Lentiviral Activation Particles (h) - sc-417164-LAC from Santa Cruz Biotechnology
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ASGPR2 Lentiviral Activation Particles (h2) - sc-417164-LAC-2 from Santa Cruz Biotechnology
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ASGPR2 siRNA (h) - sc-39872 from Santa Cruz Biotechnology
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ASGPR2 shRNA Plasmid (h) - sc-39872-SH from Santa Cruz Biotechnology
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ASGPR2 shRNA (h) Lentiviral Particles - sc-39872-V from Santa Cruz Biotechnology
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Asialoglycoprotein Receptor 2 RNAi - H00000433-R07 from Novus Biologicals
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Asialoglycoprotein Receptor 2 RNAi - H00000433-R05 from Novus Biologicals
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Asialoglycoprotein Receptor 2 RNAi - H00000433-R08 from Novus Biologicals
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MISSION® esiRNA - EHU078601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3595 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3595 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02444 from Sigma-Aldrich
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ASGR2 siRNA (Human) - CRH0312 from Cohesion Biosciences
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Asialoglycoprotein Receptor 2 RNAi - H00000433-R06 from Novus Biologicals
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ASGR2 - MBS8231139 from MyBioSource
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shRNA set against Human ASGR2 (NM_001181.4) - SHH241466 from Creative biogene
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Human ASGR2 siRNA - orb260814 from Biorbyt
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ASGR2 shRNA Plasmid (Human) - CHH0312 from Cohesion Biosciences
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ASGR2 miRNA 3'UTR clone - MiUTR3H-00209 from Creative biogene
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