Gene Symbol | CYP24A1 |
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Entrez Gene | 1591 |
Alt Symbol | CP24, CYP24, HCAI, P450-CC24 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 24, subfamily A, polypeptide 1 |
Other Description | 1,25-@dihydroxyvitamin D3 24-hydroxylase|1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial|24-OHase|cytochrome P450 24A1|cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)|cytochrome P450-CC24|exo-mitochondrial protein|vitamin D 24-hydroxylase|vitamin D(3) 24-hydroxylase |
Swissprots | Q15807 Q07973 Q5I2W7 Q32ML3 |
Accessions | AAB03776 EAW75573 Q07973 AI400154 AW022349 AY858838 AAW50795 BC109083 AAI09084 BC109084 AAI09085 BI491491 BM928702 BU662901 CN311231 L13286 AAA62379 N29030 S67623 AAB29308 XM_005260304 XP_005260361 NM_000782 NP_000773 NM_001128915 NP_001122387 |
Function | Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. |
Subcellular Location | Mitochondrion. |
Top Pathways | MicroRNAs in cancer, Steroid biosynthesis |
CYP24 (E-7) - sc-365700 from Santa Cruz Biotechnology
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CYP24 (G-15) - sc-32165 from Santa Cruz Biotechnology
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CYP24 (H-87) - sc-66851 from Santa Cruz Biotechnology
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CYP24 (S-20) - sc-32164 from Santa Cruz Biotechnology
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CYP24 (C-18) - sc-32166 from Santa Cruz Biotechnology
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Anti-CYP24A1 antibody - ab189322 from Abcam
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Anti-CYP24A1 antibody - ab96691 from Abcam
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Anti-CYP24A1 antibody - ab109632 from Abcam
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Anti-CYP24A1 antibody - ab136106 from Abcam
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Anti-CYP24A1 antibody - ab54594 from Abcam
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Anti-CYP24A1 antibody [EPR9394] - ab137116 from Abcam
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Anti-CYP24A1 antibody - C-terminal - ab175976 from Abcam
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Anti-CYP24 / CYP24A1 Antibody (aa411-460) - LS-C119489 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (aa420-469) - LS-C135726 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (aa263-312) - LS-C135727 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (aa390-439) - LS-C291854 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (aa260-514, Biotin) - LS-C299535 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (aa260-514, FITC) - LS-C303890 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (aa260-514) - LS-C293634 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (Arg439) - LS-C176852 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (aa241-514) - LS-C185746 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (clone 1E1) - LS-C197015 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (Internal) IHC-plus™ - LS-B9225 from LifeSpan Bioscience
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Anti-CYP24 / CYP24A1 Antibody (aa473-502) - LS-C167212 from LifeSpan Bioscience
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CYP24A1 Antibody (1E1.) - H00001591-M02 from Novus Biologicals
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