Gene Symbol | CYP24A1 |
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Entrez Gene | 1591 |
Alt Symbol | CP24, CYP24, HCAI, P450-CC24 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 24, subfamily A, polypeptide 1 |
Other Description | 1,25-@dihydroxyvitamin D3 24-hydroxylase|1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial|24-OHase|cytochrome P450 24A1|cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)|cytochrome P450-CC24|exo-mitochondrial protein|vitamin D 24-hydroxylase|vitamin D(3) 24-hydroxylase |
Swissprots | Q15807 Q07973 Q5I2W7 Q32ML3 |
Accessions | AAB03776 EAW75573 Q07973 AI400154 AW022349 AY858838 AAW50795 BC109083 AAI09084 BC109084 AAI09085 BI491491 BM928702 BU662901 CN311231 L13286 AAA62379 N29030 S67623 AAB29308 XM_005260304 XP_005260361 NM_000782 NP_000773 NM_001128915 NP_001122387 |
Function | Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. |
Subcellular Location | Mitochondrion. |
Top Pathways | MicroRNAs in cancer, Steroid biosynthesis |
Human CYP24A1 protein fragment - ab152322 from Abcam
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CYP24 / CYP24A1 Antibody Blocking Peptide - LS-E27526 from LifeSpan Bioscience
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CYP24 / CYP24A1 Antibody Blocking Peptide - LS-E22025 from LifeSpan Bioscience
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CYP24 / CYP24A1 Antibody Blocking Peptide - LS-E22026 from LifeSpan Bioscience
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CYP24 / CYP24A1 Antibody Blocking Peptide - LS-E9698 from LifeSpan Bioscience
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Recombinant Human CYP24A1 Protein - H00001591-Q01 from Novus Biologicals
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CYP24A1-Antibody-C-term-Blocking-Peptide - BP8648b from Abgent, a WuXi AppTec company
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CYP24A1 Blocking Peptide - 33R-5247 from Fitzgerald
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CYP24A1 Blocking Peptide - 33R-7779 from Fitzgerald
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CYP24A1 Peptide - AC21-2349-P from Abcore
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CYP24A1 - H00001591-Q01-10 from Acris Antibodies
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CYP24A1 - H00001591-Q01-25 from Acris Antibodies
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CYP24A1 Peptide - 42-693P from ProSci
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CYP24A1 fusion protein - Ag17089 from Proteintech Group
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CYP24A1 fusion protein - Ag16134 from Proteintech Group
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Recombinant Human CYP24A1, His-tagged - CYP24A1-11768H from Creative Biomart
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Recombinant Human CYP24A1, GST-tagged - CYP24A1-120H from Creative Biomart
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Recombinant Human CYP24A1, GST-tagged - CYP24A1-251H from Creative Biomart
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Recombinant Cytochrome P450 24A1 (CYP24A1) - RPD543Hu01 from Uscn Life Science Inc.
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Recombinant Cytochrome P450 24A1 (CYP24A1) - RPD543Mu01 from Uscn Life Science Inc.
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CYP24A1 (R439) Peptide - BS2190P from Bioworld Technology
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Recombinant Cytochrome P450 24A1 (CYP24A1) - RPD543Hu01 from Cloud-clone
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CYP24A1 Protein - abx164098 from Abbexa
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Cytochrome P450 24A1 Protein (Recombinant) - abx166986 from Abbexa
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CYP24A1, Peptide - MBS427430 from MyBioSource
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