| Gene Symbol | CYP24A1 |
|---|---|
| Entrez Gene | 1591 |
| Alt Symbol | CP24, CYP24, HCAI, P450-CC24 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 24, subfamily A, polypeptide 1 |
| Other Description | 1,25-@dihydroxyvitamin D3 24-hydroxylase|1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial|24-OHase|cytochrome P450 24A1|cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)|cytochrome P450-CC24|exo-mitochondrial protein|vitamin D 24-hydroxylase|vitamin D(3) 24-hydroxylase |
| Swissprots | Q15807 Q07973 Q5I2W7 Q32ML3 |
| Accessions | AAB03776 EAW75573 Q07973 AI400154 AW022349 AY858838 AAW50795 BC109083 AAI09084 BC109084 AAI09085 BI491491 BM928702 BU662901 CN311231 L13286 AAA62379 N29030 S67623 AAB29308 XM_005260304 XP_005260361 NM_000782 NP_000773 NM_001128915 NP_001122387 |
| Function | Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. |
| Subcellular Location | Mitochondrion. |
| Top Pathways | MicroRNAs in cancer, Steroid biosynthesis |