Gene Symbol | BAG4 |
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Entrez Gene | 9530 |
Alt Symbol | BAG-4, SODD |
Species | Human |
Gene Type | protein-coding |
Description | BCL2-associated athanogene 4 |
Other Description | BAG family molecular chaperone regulator 4|BAG-family molecular chaperone regulator-4|bcl-2-associated athanogene 4|silencer of death domains |
Swissprots | O95818 B4E217 O95429 |
Accessions | EAW63330 EAW63331 O95429 AF095194 AAD16123 AF111116 AAD05226 AI640615 AK304072 BAG64979 AK314020 BAG36731 AL049466 BC000800 BC038505 AAH38505 BM683128 NM_001204878 NP_001191807 NM_004874 NP_004865 |
Function | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Ubiquitous. |
Top Pathways | TNF signaling pathway |
SODD CRISPR/Cas9 KO Plasmid (h) - sc-405641 from Santa Cruz Biotechnology
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SODD HDR Plasmid (h) - sc-405641-HDR from Santa Cruz Biotechnology
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SODD Double Nickase Plasmid (h) - sc-405641-NIC from Santa Cruz Biotechnology
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SODD Double Nickase Plasmid (h2) - sc-405641-NIC-2 from Santa Cruz Biotechnology
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SODD CRISPR Activation Plasmid (h) - sc-405641-ACT from Santa Cruz Biotechnology
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SODD CRISPR Activation Plasmid (h2) - sc-405641-ACT-2 from Santa Cruz Biotechnology
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SODD Lentiviral Activation Particles (h) - sc-405641-LAC from Santa Cruz Biotechnology
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SODD Lentiviral Activation Particles (h2) - sc-405641-LAC-2 from Santa Cruz Biotechnology
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SODD siRNA (h) - sc-106839 from Santa Cruz Biotechnology
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SODD shRNA Plasmid (h) - sc-106839-SH from Santa Cruz Biotechnology
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SODD shRNA (h) Lentiviral Particles - sc-106839-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU131421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3838 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3838 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04608 from Sigma-Aldrich
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BAG4 siRNA (Human) - CRH6335 from Cohesion Biosciences
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BAG4 - MBS8220895 from MyBioSource
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shRNA set against Human BAG4 (NM_004874.3) - SHH244654 from Creative biogene
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shRNA set against Human BAG4(NM_004874.3) - SHG090453 from Creative biogene
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BAG4 shRNA Plasmid (Human) - CHH6335 from Cohesion Biosciences
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BAG4 miRNA 3'UTR clone - MiUTR1H-00788 from Creative biogene
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