PDZK1

Gene Symbol	PDZK1
Entrez Gene	5174
Alt Symbol	CAP70, CLAMP, NHERF-3, NHERF3, PDZD1
Species	Human
Gene Type	protein-coding
Description	PDZ domain containing 1
Other Description	CFTR-associated protein of 70 kDa|Na(+)/H(+) exchange regulatory cofactor NHE-RF3|PDZ-containing kidney protein 1|na/Pi cotransporter C-terminal-associated protein 1|naPi-Cap1|sodium-hydrogen exchanger regulatory factor 3
Swissprots	O60450 Q5T5P6 Q9BQ41 B4DPB9 Q5T2W1 E7EU02
Accessions	CAI13715 CAI13716 EAW71441 EAW71442 EAW71443 Q5T2W1 AF012281 AAC12264 AK298269 BAG60531 AK313100 BAG35924 AM393525 CAL38402 BC006496 AAH06496 BC006518 AAH06518 BX477678 XM_011509616 XP_011507918 XM_011509617 XP_011507919 XM_011509618 XP_011507920 XM_011509619 XP_011507921 NM_001201325 NP_001188254 NM_001201326 NP_001188255 NM_002614 NP_002605
Function	A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes (By similarity). {ECO:0000250}.
Tissue Specificity	Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas. {ECO:0000269|PubMed:10496535, ECO:0000269|PubMed:11051556, ECO:0000269|PubMed:9461128}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDZK1 (E-9) - sc-390964 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PDZK1 (H-47) - sc-292971 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PDZK1 (L-12) - sc-27279 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PDZK1 (F-36) - sc-100337 from Santa Cruz Biotechnology Prices $295.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-PDZK1 antibody - ab83549 from Abcam Prices $378.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PDZK1 antibody - ab121230 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PDZK1 antibody - ab89452 from Abcam Host Mouse Clonality Monoclonal

Anti-PDZK1 antibody - ab123798 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PDZK1 antibody [1E9] - ab125094 from Abcam Host Mouse Clonality Monoclonal Clone 1E9

Anti-PDZK1 antibody [EPR3751] - ab92491 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3751

Anti-PDZK1 Antibody (clone 1C3-2B11) IHC-plus™ - LS-B6114 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 1C3-2B11

Anti-PDZK1 Antibody (clone 1E9) IHC-plus™ - LS-B6115 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 1E9

Anti-PDZK1 Antibody (C-Terminus) - LS-C93150 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (aa1-519) - LS-C131342 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-PDZK1 Antibody (N-Terminus) - LS-C101918 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (aa80-129) - LS-C116974 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (aa196-224, AP) - LS-C266024 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (aa196-224, APC) - LS-C266025 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (aa196-224, FITC) - LS-C266026 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (aa196-224, Biotin) - LS-C266027 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (aa196-224, Azide-free, HRP) - LS-C266028 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (aa196-224, PE) - LS-C266030 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (FITC) - LS-C317607 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody (Biotin) - LS-C317606 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PDZK1 Antibody - LS-C317608 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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