PDZK1

Gene Symbol	PDZK1
Entrez Gene	5174
Alt Symbol	CAP70, CLAMP, NHERF-3, NHERF3, PDZD1
Species	Human
Gene Type	protein-coding
Description	PDZ domain containing 1
Other Description	CFTR-associated protein of 70 kDa|Na(+)/H(+) exchange regulatory cofactor NHE-RF3|PDZ-containing kidney protein 1|na/Pi cotransporter C-terminal-associated protein 1|naPi-Cap1|sodium-hydrogen exchanger regulatory factor 3
Swissprots	O60450 Q5T5P6 Q9BQ41 B4DPB9 Q5T2W1 E7EU02
Accessions	CAI13715 CAI13716 EAW71441 EAW71442 EAW71443 Q5T2W1 AF012281 AAC12264 AK298269 BAG60531 AK313100 BAG35924 AM393525 CAL38402 BC006496 AAH06496 BC006518 AAH06518 BX477678 XM_011509616 XP_011507918 XM_011509617 XP_011507919 XM_011509618 XP_011507920 XM_011509619 XP_011507921 NM_001201325 NP_001188254 NM_001201326 NP_001188255 NM_002614 NP_002605
Function	A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes (By similarity). {ECO:0000250}.
Tissue Specificity	Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas. {ECO:0000269|PubMed:10496535, ECO:0000269|PubMed:11051556, ECO:0000269|PubMed:9461128}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PDZK1 full length protein - ab114476 from Abcam Category Protein Source Wheat germ Species Human

Human PDZK1 peptide - ab86227 from Abcam Category Peptide

PDZK1 Antibody Blocking Peptide - LS-E3648 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDZK1 Antibody Blocking Peptide - LS-E15278 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDZK1 Antibody Blocking Peptide - LS-E15279 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDZK1 Recombinant Protein - H00005174-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PDZK1 Protein - NBP2-23318 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

PDZK1-Antibody-Center-Blocking-Peptide - BP14851c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PDZK1 protein - orb244852 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PDZK1 Blocking Peptide - 33R-6893 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDZK1 Blocking Peptide - 33R-6566 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDZK1 protein (His tag) - 80R-2780 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

PDZD1 (1-519, His-tag) - AR50899PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PDZD1 (1-519, His-tag) - AR50899PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PDZD1 - H00005174-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDZD1 - H00005174-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDZK1, 1-519aa, Human His tag, E.coli - 01-P2075 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

PDZK1 fusion protein - Ag24218 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET28a Species Human

PDZK1 fusion protein - Ag0787 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PDZK1 - PDZK1-30832TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PDZK1, GST-tagged - PDZK1-1633H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PDZ domain containing 1, His-tagged - PDZK1-560H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Na(+)/H(+) exchange regulatory cofactor NHE-RF3(PDZK1) - CSB-YP722565HU CSB-BP722565HU CSB-MP722565HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Na(+)/H(+) exchange regulatory cofactor NHE-RF3 - CSB-EP722565HU from Cusabio Category Protein Source E.coli Species Human

PDZK1, 1-519aa, Human His tag, E.coli - ATGP2075 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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