PDZK1
| Gene Symbol | PDZK1 |
|---|---|
| Entrez Gene | 5174 |
| Alt Symbol | CAP70, CLAMP, NHERF-3, NHERF3, PDZD1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | PDZ domain containing 1 |
| Other Description | CFTR-associated protein of 70 kDa|Na(+)/H(+) exchange regulatory cofactor NHE-RF3|PDZ-containing kidney protein 1|na/Pi cotransporter C-terminal-associated protein 1|naPi-Cap1|sodium-hydrogen exchanger regulatory factor 3 |
| Swissprots | O60450 Q5T5P6 Q9BQ41 B4DPB9 Q5T2W1 E7EU02 |
| Accessions | CAI13715 CAI13716 EAW71441 EAW71442 EAW71443 Q5T2W1 AF012281 AAC12264 AK298269 BAG60531 AK313100 BAG35924 AM393525 CAL38402 BC006496 AAH06496 BC006518 AAH06518 BX477678 XM_011509616 XP_011507918 XM_011509617 XP_011507919 XM_011509618 XP_011507920 XM_011509619 XP_011507921 NM_001201325 NP_001188254 NM_001201326 NP_001188255 NM_002614 NP_002605 |
| Function | A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of |
| Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas. {ECO:0000269|PubMed:10496535, ECO:0000269|PubMed:11051556, ECO:0000269|PubMed:9461128}. |
PDZK1 CRISPR/Cas9 KO Plasmid (h) - sc-417176 from Santa Cruz Biotechnology
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PDZK1 HDR Plasmid (h) - sc-417176-HDR from Santa Cruz Biotechnology
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PDZK1 Double Nickase Plasmid (h) - sc-417176-NIC from Santa Cruz Biotechnology
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PDZK1 Double Nickase Plasmid (h2) - sc-417176-NIC-2 from Santa Cruz Biotechnology
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PDZK1 CRISPR Activation Plasmid (h) - sc-417176-ACT from Santa Cruz Biotechnology
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PDZK1 CRISPR Activation Plasmid (h2) - sc-417176-ACT-2 from Santa Cruz Biotechnology
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PDZK1 Lentiviral Activation Particles (h) - sc-417176-LAC from Santa Cruz Biotechnology
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PDZK1 Lentiviral Activation Particles (h2) - sc-417176-LAC-2 from Santa Cruz Biotechnology
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PDZK1 siRNA (h) - sc-106840 from Santa Cruz Biotechnology
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PDZK1 shRNA Plasmid (h) - sc-106840-SH from Santa Cruz Biotechnology
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PDZK1 shRNA (h) Lentiviral Particles - sc-106840-V from Santa Cruz Biotechnology
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PDZK1 RNAi - H00005174-R01 from Novus Biologicals
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MISSION® esiRNA - EHU101831 from Sigma-Aldrich
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MISSION® esiRNA - EHU104911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16597 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16597 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04896 from Sigma-Aldrich
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PDZK1 siRNA (Human) - CRH3453 from Cohesion Biosciences
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shRNA set against Human PDZK1 (NM_002614.4) - SHH373260 from Creative biogene
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Human PDZK1 siRNA - orb263955 from Biorbyt
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PDZK1 shRNA Plasmid (Human) - CHH3453 from Cohesion Biosciences
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PDZK1 miRNA 3'UTR clone - MiUTR3H-06300 from Creative biogene
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