| Gene Symbol |
Socs2
|
| Entrez Gene |
84607
|
| Alt Symbol |
Cish2, Socs-2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
suppressor of cytokine signaling 2
|
| Other Description |
cytokine inducible SH2-containing protein 2|cytokine-inducible SH2 protein 2
|
| Swissprots |
O88582
|
| Accessions |
CAB64205 EDM16862 EDM16863 EDM16864 EDM16865 EDM16866 EDM16867 O88582 AF075382 AAC26222 NM_058208 NP_478115
|
| Function |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
|
| Top Pathways |
Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Prolactin signaling pathway
|