| Gene Symbol | Socs2 |
|---|---|
| Entrez Gene | 84607 |
| Alt Symbol | Cish2, Socs-2 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | suppressor of cytokine signaling 2 |
| Other Description | cytokine inducible SH2-containing protein 2|cytokine-inducible SH2 protein 2 |
| Swissprots | O88582 |
| Accessions | CAB64205 EDM16862 EDM16863 EDM16864 EDM16865 EDM16866 EDM16867 O88582 AF075382 AAC26222 NM_058208 NP_478115 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}. |
| Top Pathways | Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Prolactin signaling pathway |
CompoZr® Knockout ZFN Kit - CKOZFN63307 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND63307 from Sigma-Aldrich
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SOCS2 siRNA (Rat) - CRR2636 from Cohesion Biosciences
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SOCS2 - MBS8232535 from MyBioSource
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shRNA set against Rat SOCS2 (NM_058208.1) - SHH414960 from Creative biogene
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shRNA set against Rat Socs2(NM_058208.1) - SHL024258 from Creative biogene
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SOCS2 shRNA Plasmid (Rat) - CHR2636 from Cohesion Biosciences
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