| Gene Symbol | KLK11 |
|---|---|
| Entrez Gene | 11012 |
| Alt Symbol | PRSS20, TLSP |
| Species | Human |
| Gene Type | protein-coding |
| Description | kallikrein-related peptidase 11 |
| Other Description | hK11|hippostasin|kallikrein 11|kallikrein-11|serine protease 20|trypsin-like protease |
| Swissprots | Q8IXD7 Q9NS65 Q0WXX5 O75837 Q9UBX7 |
| Accessions | AAD47815 AAG23257 AAG33364 EAW71970 EAW71971 EAW71972 Q9UBX7 AB012917 BAA33404 AB013730 BAA88713 AB041036 BAA96797 AB078780 BAC54105 AB259014 BAF02733 AB261897 BAE95335 AK308207 AY359014 AAQ89373 BC015551 BC022068 AAH22068 BG697071 HQ447348 ADQ31834 XM_005258439 XP_005258496 XM_011526369 XP_011524671 XM_011526370 XP_011524672 XM_011526371 XP_011524673 XM_011526372 XP_011524674 XM_011526373 XP_011524675 NM_001136032 NP_001129504 NM_001167605 NP_001161077 NM_006853 NP_006844 NM_144947 NP_659196 |
| Function | Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. {ECO:0000269|PubMed:10872828, ECO:0000269|PubMed:16467084}. |
| Subcellular Location | Isoform 1: Secreted. |
| Tissue Specificity | Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level). {ECO:0000269|PubMed:10872828, ECO:0000269|PubMed:16467084}. |
KLK11 CRISPR/Cas9 KO Plasmid (h) - sc-409543 from Santa Cruz Biotechnology
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KLK11 HDR Plasmid (h) - sc-409543-HDR from Santa Cruz Biotechnology
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KLK11 Double Nickase Plasmid (h) - sc-409543-NIC from Santa Cruz Biotechnology
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KLK11 Double Nickase Plasmid (h2) - sc-409543-NIC-2 from Santa Cruz Biotechnology
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KLK11 CRISPR Activation Plasmid (h) - sc-409543-ACT from Santa Cruz Biotechnology
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KLK11 CRISPR Activation Plasmid (h2) - sc-409543-ACT-2 from Santa Cruz Biotechnology
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KLK11 Lentiviral Activation Particles (h) - sc-409543-LAC from Santa Cruz Biotechnology
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KLK11 Lentiviral Activation Particles (h2) - sc-409543-LAC-2 from Santa Cruz Biotechnology
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KLK11 siRNA (h) - sc-41540 from Santa Cruz Biotechnology
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KLK11 shRNA Plasmid (h) - sc-41540-SH from Santa Cruz Biotechnology
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KLK11 shRNA (h) Lentiviral Particles - sc-41540-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU059081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11305 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11305 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02280 from Sigma-Aldrich
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KLK11 siRNA (Human) - CRH7521 from Cohesion Biosciences
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shRNA set against Human KLK11 (NM_006853.2) - SHH326455 from Creative biogene
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shRNA set against Human KLK11(NM_144947.1) - SHL201744 from Creative biogene
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shRNA set against Human KLK11(NM_006853.2) - SHL202078 from Creative biogene
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shRNA set against Human KLK11(NM_144947.1) - SHL202094 from Creative biogene
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Human KLK11 siRNA - orb268023 from Biorbyt
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KLK11 shRNA Plasmid (Human) - CHH7521 from Cohesion Biosciences
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KLK11 miRNA 3'UTR clone - MiUTR1H-05386 from Creative biogene
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KLK11 miRNA 3'UTR clone - MiUTR1H-05387 from Creative biogene
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KLK11 miRNA 3'UTR clone - MiUTR3H-06796 from Creative biogene
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