Gene Symbol | RBBP8 |
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Entrez Gene | 5932 |
Alt Symbol | COM1, CTIP, JWDS, RIM, SAE2, SCKL2 |
Species | Human |
Gene Type | protein-coding |
Description | retinoblastoma binding protein 8 |
Other Description | CTBP-interacting protein|DNA endonuclease RBBP8|RBBP-8|sporulation in the absence of SPO11 protein 2 homolog |
Swissprots | Q8NHQ3 E7ETY1 A8K8W6 Q99708 A6NKN2 O75371 |
Accessions | EAX01143 EAX01144 EAX01145 EAX01146 Q99708 AF043431 AAC34368 AK292481 BAF85170 BC001170 BC030590 AAH30590 BG723261 BU187672 BX648221 DQ890956 ABM81882 DQ894119 ABM85045 U72066 AAC14371 XM_005258325 XP_005258382 XM_005258326 XP_005258383 XM_006722519 XP_006722582 XM_006722520 XP_006722583 XM_006722521 XP_006722584 XM_011526132 XP_011524434 NM_002894 NP_002885 NM_203291 NP_976036 NM_203292 NP_976037 |
Function | Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations. {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:20829486}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:17965729}. Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage. |
CtIP (D76F7) Rabbit mAb - 9201 from Cell Signaling Technology
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CtIP (D-4) - sc-271339 from Santa Cruz Biotechnology
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CtIP (E-2) - sc-48415 from Santa Cruz Biotechnology
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CtIP (K-19) - sc-5969 from Santa Cruz Biotechnology
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CtIP (H-300) - sc-22838 from Santa Cruz Biotechnology
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CtIP (F-2) - sc-28324 from Santa Cruz Biotechnology
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CtIP (T-16) - sc-5970 from Santa Cruz Biotechnology
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Anti-CtIP antibody - ab38016 from Abcam
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Anti-CtIP antibody - ab117722 from Abcam
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Anti-CtIP antibody - ab110143 from Abcam
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Anti-CtIP antibody - ab96773 from Abcam
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Anti-CtIP antibody - ab70162 from Abcam
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Anti-CtIP antibody [EPNCIR160] - ab155988 from Abcam
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Anti-CtIP antibody - ChIP Grade - ab70163 from Abcam
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Anti-RBBP8 / CTIP Antibody IHC-plus⢠- LS-B4843 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody (Internal) IHC-plus⢠- LS-B5273 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody (clone 19E8) - LS-C20066 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody - LS-C125234 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody (aa293-342) - LS-C117598 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody (aa686-735) - LS-C81608 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody (aa630-679) - LS-C199521 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody (aa763-792, AP) - LS-C207555 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody (aa763-792, APC) - LS-C207556 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody (aa763-792, FITC) - LS-C207558 from LifeSpan Bioscience
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Anti-RBBP8 / CTIP Antibody (aa763-792, Biotin) - LS-C207557 from LifeSpan Bioscience
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