RBBP8

Gene Symbol RBBP8
Entrez Gene 5932
Alt Symbol COM1, CTIP, JWDS, RIM, SAE2, SCKL2
Species Human
Gene Type protein-coding
Description retinoblastoma binding protein 8
Other Description CTBP-interacting protein|DNA endonuclease RBBP8|RBBP-8|sporulation in the absence of SPO11 protein 2 homolog
Swissprots Q8NHQ3 E7ETY1 A8K8W6 Q99708 A6NKN2 O75371
Accessions EAX01143 EAX01144 EAX01145 EAX01146 Q99708 AF043431 AAC34368 AK292481 BAF85170 BC001170 BC030590 AAH30590 BG723261 BU187672 BX648221 DQ890956 ABM81882 DQ894119 ABM85045 U72066 AAC14371 XM_005258325 XP_005258382 XM_005258326 XP_005258383 XM_006722519 XP_006722582 XM_006722520 XP_006722583 XM_006722521 XP_006722584 XM_011526132 XP_011524434 NM_002894 NP_002885 NM_203291 NP_976036 NM_203292 NP_976037
Function Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations. {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:20829486}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:17965729}. Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage.

CtIP (D76F7) Rabbit mAb - 9201 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D76F7
Western blot analysis of extracts from various cell lines using CtIP (D76F7) Rabbit mAb.

CtIP (D-4) - sc-271339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CtIP (D-4): sc-271339. Western blot analysis of CtIP expression in HeLa whole cell lysate.

CtIP (E-2) - sc-48415 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CtIP (E-2): sc-48415. Western blot analysis of CtIP expression in T24 whole cell lysate (A) and Jurkat nuclear extract (B).

CtIP (K-19) - sc-5969 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CtIP (K-19): sc-5969. Western blot analysis of CtIP expression in non-transfected: sc-117752 (A) and mouse CtIP transfected: sc-119500 (B) 293T whole cell lysates.

CtIP (H-300) - sc-22838 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CtIP (H-300): sc-22838. Western blot analysis of CtIP expression in non-transfected: sc-117752 (A) and mouse CtIP transfected: sc-119500 (B) 293T whole cell lysates.

CtIP (F-2) - sc-28324 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CtIP (F-2): sc-28324. Western blot analysis of CtIP expression in T24 whole cell lysate (A) and Jurkat nuclear extract (B).

CtIP (T-16) - sc-5970 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CtIP (T-16): sc-5970. Western blot analysis of CtIP expression in non-transfected: sc-117752 (A) and mouse CtIP transfected: sc-119500 (B) 293T whole cell lysates.

Anti-CtIP antibody - ab38016 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CtIP antibody (ab38016) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 2 : HeLa (Human epithelial carcinoma cell line) Nuclear Lysate Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 4 : HepG2 (Human hepatocellular liver carcinoma cell line) Nuclear Lysate (ab14660)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-CtIP antibody - ab117722 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry Image of Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) stained with anti-CTIP antibody (ab117722).

Anti-CtIP antibody - ab110143 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab110143, at 1/50 dilution, staining CtIP in paraffin-embedded Human thyroid gland tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of the immunizing peptide.

Anti-CtIP antibody - ab96773 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CtIP antibody (ab96773) at 1/5000 dilution + Hep G2 whole cell lysate at 30 µg

Anti-CtIP antibody - ab70162 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CtIP antibody [EPNCIR160] - ab155988 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPNCIR160
All lanes : Anti-CtIP antibody [EPNCIR160] (ab155988) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : MCF-7 cell lysate Lysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-CtIP antibody - ChIP Grade - ab70163 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CtIP antibody - ChIP Grade (ab70163) at 1 µg/mlLane 1 : MCF7 whole cell lysate at 50 µgLane 2 : MCF7 whole cell lysate at 15 µgLane 3 : MCF7 whole cell lysate at 5 µgLane 4 : HeLa whole cell lysate at 50 µg

Anti-RBBP8 / CTIP Antibody IHC-plus™ - LS-B4843 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-RBBP8 / CTIP antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4843 concentration 10 ug/ml.

Anti-RBBP8 / CTIP Antibody (Internal) IHC-plus™ - LS-B5273 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RBBP8 / CTIP antibody IHC of human pancreas, duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5273 concentration 5 ug/ml.

Anti-RBBP8 / CTIP Antibody (clone 19E8) - LS-C20066 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 19E8

Anti-RBBP8 / CTIP Antibody - LS-C125234 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RBBP8 / CTIP Antibody (aa293-342) - LS-C117598 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human lung carcinoma tissue, using CTIP (Ab-327) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-RBBP8 / CTIP Antibody (aa686-735) - LS-C81608 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Placenta lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-RBBP8 / CTIP Antibody (aa630-679) - LS-C199521 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human thyroid gland tissue, using RBBP8 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-RBBP8 / CTIP Antibody (aa763-792, AP) - LS-C207555 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP8 / CTIP Antibody (aa763-792, APC) - LS-C207556 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP8 / CTIP Antibody (aa763-792, FITC) - LS-C207558 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP8 / CTIP Antibody (aa763-792, Biotin) - LS-C207557 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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