| Gene Symbol |
RBBP8
|
| Entrez Gene |
5932
|
| Alt Symbol |
COM1, CTIP, JWDS, RIM, SAE2, SCKL2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoblastoma binding protein 8
|
| Other Description |
CTBP-interacting protein|DNA endonuclease RBBP8|RBBP-8|sporulation in the absence of SPO11 protein 2 homolog
|
| Swissprots |
Q8NHQ3 E7ETY1 A8K8W6 Q99708 A6NKN2 O75371
|
| Accessions |
EAX01143 EAX01144 EAX01145 EAX01146 Q99708 AF043431 AAC34368 AK292481 BAF85170 BC001170 BC030590 AAH30590 BG723261 BU187672 BX648221 DQ890956 ABM81882 DQ894119 ABM85045 U72066 AAC14371 XM_005258325 XP_005258382 XM_005258326 XP_005258383 XM_006722519 XP_006722582 XM_006722520 XP_006722583 XM_006722521 XP_006722584 XM_011526132 XP_011524434 NM_002894 NP_002885 NM_203291 NP_976036 NM_203292 NP_976037
|
| Function |
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations. {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:20829486}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:17965729}. Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage.
|