RBBP8

Gene Symbol RBBP8
Entrez Gene 5932
Alt Symbol COM1, CTIP, JWDS, RIM, SAE2, SCKL2
Species Human
Gene Type protein-coding
Description retinoblastoma binding protein 8
Other Description CTBP-interacting protein|DNA endonuclease RBBP8|RBBP-8|sporulation in the absence of SPO11 protein 2 homolog
Swissprots Q8NHQ3 E7ETY1 A8K8W6 Q99708 A6NKN2 O75371
Accessions EAX01143 EAX01144 EAX01145 EAX01146 Q99708 AF043431 AAC34368 AK292481 BAF85170 BC001170 BC030590 AAH30590 BG723261 BU187672 BX648221 DQ890956 ABM81882 DQ894119 ABM85045 U72066 AAC14371 XM_005258325 XP_005258382 XM_005258326 XP_005258383 XM_006722519 XP_006722582 XM_006722520 XP_006722583 XM_006722521 XP_006722584 XM_011526132 XP_011524434 NM_002894 NP_002885 NM_203291 NP_976036 NM_203292 NP_976037
Function Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations. {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:15485915, ECO:0000269|PubMed:16581787, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17965729, ECO:0000269|PubMed:19202191, ECO:0000269|PubMed:19759395, ECO:0000269|PubMed:20064462, ECO:0000269|PubMed:20829486}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10764811, ECO:0000269|PubMed:17965729}. Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage.

CtIP CRISPR/Cas9 KO Plasmid (h) - sc-401292 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CtIP HDR Plasmid (h) - sc-401292-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CtIP Double Nickase Plasmid (h) - sc-401292-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CtIP Double Nickase Plasmid (h2) - sc-401292-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CtIP CRISPR Activation Plasmid (h) - sc-401292-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CtIP CRISPR Activation Plasmid (h2) - sc-401292-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CtIP Lentiviral Activation Particles (h) - sc-401292-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CtIP Lentiviral Activation Particles (h2) - sc-401292-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CtIP siRNA (h) - sc-37765 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CtIP shRNA Plasmid (h) - sc-37765-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CtIP shRNA (h) Lentiviral Particles - sc-37765-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU070611 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18014 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18014 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01472 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01472

RBBP8 siRNA (Human) - CRH4018 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RBBP8 - MBS8226387 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RBBP8 (NM_002894.2) - SHH390384 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human RBBP8(NM_203292.1) - SHR167926 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human RBBP8(NM_002894.2) - SHR167944 from Creative biogene

Category siRNA
Species Reactivities Human

Human RBBP8 siRNA - orb264520 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RBBP8 shRNA Plasmid (Human) - CHH4018 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RBBP8 miRNA 3'UTR clone - MiUTR1H-08669 from Creative biogene

Species Reactivities Human

RBBP8 miRNA 3'UTR clone - MiUTR1H-08670 from Creative biogene

Species Reactivities Human

RBBP8 miRNA 3'UTR clone - MiUTR3H-06575 from Creative biogene

Species Reactivities Human
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