Gene Symbol | B3GALT2 |
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Entrez Gene | 8707 |
Alt Symbol | BETA3GALT2, GLCT2, beta3Gal-T2 |
Species | Human |
Gene Type | protein-coding |
Description | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 |
Other Description | UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2|beta-1,3-GalTase 2|beta-1,3-galactosyltransferase 2|beta-3-galt2 |
Swissprots | B2RAB1 Q9BZQ9 O43825 |
Accessions | CAJ78385 EAW91251 O43825 AF288390 AAG60610 AK314116 BAG36808 BC022507 AAH22507 DA116294 HQ447956 ADQ32440 Y15060 CAA75344 NM_003783 NP_003774 |
Function | Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues. {ECO:0000269|PubMed:9417100, ECO:0000269|PubMed:9582303}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Detected in heart and brain. {ECO:0000269|PubMed:9417100, ECO:0000269|PubMed:9582303}. |
Top Pathways | Glycosphingolipid biosynthesis - lacto and neolacto series |
β-1,3-Gal-T2 siRNA (h) - sc-40612 from Santa Cruz Biotechnology
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β-1,3-Gal-T2 shRNA Plasmid (h) - sc-40612-SH from Santa Cruz Biotechnology
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β-1,3-Gal-T2 shRNA (h) Lentiviral Particles - sc-40612-V from Santa Cruz Biotechnology
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B3GALT2 RNAi - H00008707-R01 from Novus Biologicals
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MISSION® esiRNA - EHU002011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3797 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3797 from Sigma-Aldrich
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B3GALT2 siRNA (Human) - CRH5731 from Cohesion Biosciences
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B3GALT2 - MBS827932 from MyBioSource
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shRNA set against Human B3GALT2 (NM_003783.3) - SHH244134 from Creative biogene
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Human B3GALT2 siRNA - orb266233 from Biorbyt
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B3GALT2 shRNA Plasmid (Human) - CHH5731 from Cohesion Biosciences
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B3GALT2 miRNA 3'UTR clone - MiUTR3H-05560 from Creative biogene
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