| Gene Symbol |
HAT1
|
| Entrez Gene |
8520
|
| Alt Symbol |
KAT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone acetyltransferase 1
|
| Other Description |
histone acetyltransferase type B catalytic subunit
|
| Swissprots |
O14929 Q8WWB9 Q6P594 Q49A44 Q53QF0 Q53SU4
|
| Accessions |
AAX93247 AAY14731 EAX11194 EAX11195 O14929 AF030424 AAC02425 AK127840 AK309001 AK313699 BC018682 AAH18682 BC045673 BC063003 AAH63003 BG184638 DB050336 HQ448051 ADQ32532 XM_006712808 XP_006712871 XM_011512027 XP_011510329 NM_003642 NP_003633 NR_027862 NM_001033085
|
| Function |
Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:9427644}.
|
| Subcellular Location |
Isoform A: Nucleus matrix.
|
| Top Pathways |
Alcoholism
|
