Gene Symbol | GPHB5 |
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Entrez Gene | 122876 |
Alt Symbol | B5, GPB5, ZLUT1 |
Species | Human |
Gene Type | protein-coding |
Description | glycoprotein hormone beta 5 |
Other Description | glycoprotein beta 5|glycoprotein hormone beta subunit|glycoprotein hormone beta-5|thyrostimulin subunit beta |
Swissprots | Q86YW7 Q6NTD0 Q8NFW2 |
Accessions | CAJ32902 CAM33586 EAW80825 Q86YW7 AF403430 AAM53261 AF467770 AAO33390 BC069113 AAH69113 BC133702 AAI33703 BM709443 NM_145171 NP_660154 |
Function | Stimulates the thyroid. Binds and activates THSR, leading to increased cAMP production. {ECO:0000269|PubMed:12045258, ECO:0000269|PubMed:16210345}. |
Subcellular Location | Secreted. |
Tissue Specificity | Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs. {ECO:0000269|PubMed:12089349, ECO:0000269|PubMed:16210345}. |
GPB5 CRISPR/Cas9 KO Plasmid (h) - sc-409023 from Santa Cruz Biotechnology
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GPB5 HDR Plasmid (h) - sc-409023-HDR from Santa Cruz Biotechnology
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GPB5 Double Nickase Plasmid (h) - sc-409023-NIC from Santa Cruz Biotechnology
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GPB5 Double Nickase Plasmid (h2) - sc-409023-NIC-2 from Santa Cruz Biotechnology
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GPB5 CRISPR Activation Plasmid (h) - sc-409023-ACT from Santa Cruz Biotechnology
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GPB5 CRISPR Activation Plasmid (h2) - sc-409023-ACT-2 from Santa Cruz Biotechnology
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GPB5 Lentiviral Activation Particles (h) - sc-409023-LAC from Santa Cruz Biotechnology
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GPB5 Lentiviral Activation Particles (h2) - sc-409023-LAC-2 from Santa Cruz Biotechnology
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GPB5 siRNA (h) - sc-72242 from Santa Cruz Biotechnology
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GPB5 shRNA Plasmid (h) - sc-72242-SH from Santa Cruz Biotechnology
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GPB5 shRNA (h) Lentiviral Particles - sc-72242-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN9526 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9526 from Sigma-Aldrich
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GPHB5 siRNA (Human) - CRJ4715 from Cohesion Biosciences
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GPHB5 - MBS8224638 from MyBioSource
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shRNA set against Human GPHB5 (NM_145171.3) - SHH305874 from Creative biogene
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Human GPHB5 siRNA - orb275216 from Biorbyt
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GPHB5 shRNA Plasmid (Human) - CHJ4715 from Cohesion Biosciences
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GPHB5 miRNA 3'UTR clone - MiUTR4H-TG03927 from Creative biogene
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