| Gene Symbol |
SPEN
|
| Entrez Gene |
23013
|
| Alt Symbol |
HIAA0929, MINT, RBM15C, SHARP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spen family transcriptional repressor
|
| Other Description |
Msx2 interacting nuclear target (MINT) homolog|SMART/HDAC1 associated repressor protein|SMART/HDAC1-associated repressor protein|msx2-interacting protein|nuclear receptor transcription cofactor|spen homolog, transcriptional regulator
|
| Swissprots |
Q9NWH5 Q9Y556 Q9H9A8 Q96T58 Q9UQ01
|
| Accessions |
CBX47466 EAW51756 Q96T58 AB023146 BAA76773 AF085964 AF356524 AAK52750 AK000882 BAA91405 AK022949 BAB14324 AK092332 AK127577 AL096858 CAB51072 NM_015001 NP_055816
|
| Function |
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. {ECO:0000250, ECO:0000269|PubMed:11331609, ECO:0000269|PubMed:12374742}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11331609}. Note=Associates with chromatin.
|
| Tissue Specificity |
Expressed at high level in brain, testis, spleen and thymus. Expressed at intermediate level in kidney, liver, mammary gland and skin.
|