| Gene Symbol |
AKR1B10
|
| Entrez Gene |
57016
|
| Alt Symbol |
AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aldo-keto reductase family 1, member B10 (aldose reductase)
|
| Other Description |
ARP|SI reductase|aldo-keto reductase family 1 member B10|aldo-keto reductase family 1, member B11 (aldose reductase-like)|aldose reductase-like 1|aldose reductase-like peptide|aldose reductase-related protein|hARP|small intestine reductase
|
| Swissprots |
O60218 A4D1P1 O75890 Q8IWZ1 Q6FHF3
|
| Accessions |
EAL24069 EAW83816 O60218 AF044961 AAC15671 AF052577 AAC36465 AF524864 AAO13380 BC008837 AAH08837 BM975664 BT006794 AAP35440 CR541801 CAG46600 DQ890678 ABM81604 EU176471 ABW03272 U37100 AAC17469 XM_011516416 XP_011514718 XM_011516417 XP_011514719 XR_927491 NM_020299 NP_064695
|
| Function |
Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. {ECO:0000269|PubMed:18087047}.
|
| Subcellular Location |
Lysosome {ECO:0000269|PubMed:21585341}. Secreted {ECO:0000269|PubMed:21585341}. Note=Secreted through a lysosome-mediated non-classical pathway.
|
| Tissue Specificity |
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
|
| Top Pathways |
Pentose and glucuronate interconversions, Glycerolipid metabolism, Galactose metabolism, Fructose and mannose metabolism
|
