AKR1B10

Gene Symbol AKR1B10
Entrez Gene 57016
Alt Symbol AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member B10 (aldose reductase)
Other Description ARP|SI reductase|aldo-keto reductase family 1 member B10|aldo-keto reductase family 1, member B11 (aldose reductase-like)|aldose reductase-like 1|aldose reductase-like peptide|aldose reductase-related protein|hARP|small intestine reductase
Swissprots O60218 A4D1P1 O75890 Q8IWZ1 Q6FHF3
Accessions EAL24069 EAW83816 O60218 AF044961 AAC15671 AF052577 AAC36465 AF524864 AAO13380 BC008837 AAH08837 BM975664 BT006794 AAP35440 CR541801 CAG46600 DQ890678 ABM81604 EU176471 ABW03272 U37100 AAC17469 XM_011516416 XP_011514718 XM_011516417 XP_011514719 XR_927491 NM_020299 NP_064695
Function Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. {ECO:0000269|PubMed:18087047}.
Subcellular Location Lysosome {ECO:0000269|PubMed:21585341}. Secreted {ECO:0000269|PubMed:21585341}. Note=Secreted through a lysosome-mediated non-classical pathway.
Tissue Specificity Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Top Pathways Pentose and glucuronate interconversions, Glycerolipid metabolism, Galactose metabolism, Fructose and mannose metabolism

AKR1B10 (AA-1) - sc-100501 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
AKR1B10 (AA-1): sc-100501. Western blot analysis of AKR1B10 expression in Hep G2 whole cell lysate.

AKR1B10 (D-8) - sc-365688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKR1B10 (D-8): sc-365688. Western blot analysis of AKR1B10 expression in A549 whole cell lysate.

AKR1B10 (F-4) - sc-365689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AKR1B10 (F-4): sc-365689. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of subset of glandular cells.

AKR1B10 (H-69) - sc-135334 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AKR1B10 (H-69): sc-135334. Western blot analysis of AKR1B10 expression in HISM whole cell lysate (A) and human stomach tissue extract (B).

AKR1B10 (P-18) - sc-54352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AKR1B10 (C-14): sc-54352. Western blot analysis of AKR1B10 expression in A549 whole cell lysate.

AKR1B10 (W-18) - sc-54256 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AKR1B10 (W-18): sc-54256. Western blot analysis of AKR1B10 expression in A549 whole cell lysate.

Aldose Reductase (E-12) - sc-373953 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Aldose Reductase (E-12): sc-373953. Western blot analysis of Aldose Reductase expression in Caki-1 whole cell lysate.

Anti-AKR1B10 antibody - ab57547 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
AKR1B10 antibody (ab57547) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.

Anti-AKR1B10 antibody - ab96417 from Abcam

Prices $380.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKR1B10 antibody (ab96417) at 1/1000 dilutionLane 1 : MOLT4 whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-AKR1B10 antibody - ab62218 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-AKR1B10 antibody (ab62218) at 1.25 µg/ml + A549 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-AKR1B10 antibody - ab154956 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-AKR1B10 antibody (ab154956) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

Anti-AKR1B10 antibody - ab77378 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-AKR1B10 antibody (ab77378) at 0.03 µg/ml + A549 cell lysate (in RIPA buffer) at 35 µg

Anti-AKR1B10 antibody - ab61832 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-AKR1B10 antibody (ab61832) at 1 µg/mlLane 1 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate Lane 2 : Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-AKR1B10 antibody [1A6] - ab109998 from Abcam

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1A6
ab109998, at 5 µg/ml, staining AKR1B10 in Human small intenstine tissue by immunohistochemistry.

Anti-AKR1B10 antibody [EPR14421] - ab192865 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14421
Anti-AKR1B10 antibody [EPR14421] (ab192865) at 1/10000 dilution + A549 cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-AKR1B10 antibody [EPR9766(B)] - ab151569 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR9766(B)
All lanes : Anti-AKR1B10 antibody [EPR9766(B)] (ab151569) at 1/1000 dilutionLane 1 : A549 cell lysateLane 2 : SW480 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-AKR1B10 antibody [EPR9767(B)] - ab139685 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9767(B)
All lanes : Anti-AKR1B10 antibody [EPR9767(B)] (ab139685) at 1/1000 dilutionLane 1 : Human small intestine cell lysateLane 2 : A549 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-AKR1B10 Antibody (aa76-173, clone GF1) - LS-C190473 from LifeSpan Bioscience

Prices $830.00
Sizes 1 mg
Host Mouse
Clonality Monoclonal
Clone GF1

Anti-AKR1B10 Antibody (aa101-130, AP) - LS-C251103 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1B10 Antibody (aa101-130, FITC) - LS-C251105 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1B10 Antibody - LS-C143351 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
AKR1B10 Antibody - WB analysis of AKR1B10 expression in RKO cell lysate (Lanes 1 & 3) and HCT-8 cell lysate (Lanes 2 & 4).

Anti-AKR1B10 Antibody (aa101-130, APC) - LS-C251104 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1B10 Antibody (aa101-130, PE) - LS-C251106 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1B10 Antibody (aa100-130) - LS-C319397 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AKR1B10 Antibody (aa101-130) - LS-C156210 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
AKR1B10 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The AKR1B10 antibody detected the AKR1B10 protein (arrow).
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