| Gene Symbol |
SRGAP2
|
| Entrez Gene |
23380
|
| Alt Symbol |
ARHGAP34, FNBP2, SRGAP2A, SRGAP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SLIT-ROBO Rho GTPase activating protein 2
|
| Other Description |
SLIT-ROBO GAP2|SLIT-ROBO Rho GTPase-activating protein 2|formin-binding protein 2|rho GTPase-activating protein 34
|
| Swissprots |
O75044
|
| Accessions |
CAH73674 CAH73675 CAH73676 EAW93550 O75044 AB007925 BAA32301 AK000885 BAG50836 AK057565 AK124556 AK293335 BAG56851 AK294060 BAG57406 AK295845 BAH12200 BC041635 BC063527 BC132872 AAI32873 BC132874 AAI32875 BC144343 AAI44344 BC150646 CA447513 DA110905 S68466 XM_005277510 XP_005277567 XM_005277511 XP_005277568 XM_005277514 XP_005277571 XM_005277515 XP_005277572 XM_011509354 XP_011507656 XM_011509355 XP_011507657 XM_011509356 XP_011507658 XM_011509357 XP_011507659 XM_011509358 XP_011507660 XM_011509359 XP_011507661 XM_011509360 XP_011507662 NM_001170637 NP_001164108 NM_001300952 NP_001287881 NM_015326 NP_056141 NM_001042758
|
| Function |
RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. {ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944}.
|
| Subcellular Location |
Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates from nucleus to cytoplasm during development. {ECO:0000250}.
|
| Top Pathways |
Axon guidance
|