SRGAP2

Gene Symbol	SRGAP2
Entrez Gene	23380
Alt Symbol	ARHGAP34, FNBP2, SRGAP2A, SRGAP3
Species	Human
Gene Type	protein-coding
Description	SLIT-ROBO Rho GTPase activating protein 2
Other Description	SLIT-ROBO GAP2\|SLIT-ROBO Rho GTPase-activating protein 2\|formin-binding protein 2\|rho GTPase-activating protein 34
Swissprots	O75044
Accessions	CAH73674 CAH73675 CAH73676 EAW93550 O75044 AB007925 BAA32301 AK000885 BAG50836 AK057565 AK124556 AK293335 BAG56851 AK294060 BAG57406 AK295845 BAH12200 BC041635 BC063527 BC132872 AAI32873 BC132874 AAI32875 BC144343 AAI44344 BC150646 CA447513 DA110905 S68466 XM_005277510 XP_005277567 XM_005277511 XP_005277568 XM_005277514 XP_005277571 XM_005277515 XP_005277572 XM_011509354 XP_011507656 XM_011509355 XP_011507657 XM_011509356 XP_011507658 XM_011509357 XP_011507659 XM_011509358 XP_011507660 XM_011509359 XP_011507661 XM_011509360 XP_011507662 NM_001170637 NP_001164108 NM_001300952 NP_001287881 NM_015326 NP_056141 NM_001042758
Function	RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. {ECO:0000269\|PubMed:20810653, ECO:0000269\|PubMed:21148482, ECO:0000269\|PubMed:22559944}.
Subcellular Location	Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates from nucleus to cytoplasm during development. {ECO:0000250}.
Top Pathways	Axon guidance

FNBP2 (G-10) - sc-398399 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

FNBP2 (G-10): sc-398399. Western blot analysis of FNBP2 expression in SH-SY5Y (A) and Caki-1 (B) whole cell lysates.

FNBP2 (C-14) - sc-103497 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

FNBP2 (C-14): sc-103497. Western blot analysis of FNBP2 expression in non-transfected: sc-117752 (A) and mouse FNBP2 transfected: sc-178625 (B) 293T whole cell lysates.

FNBP2 (E-20) - sc-103498 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

FNBP2 (E-20): sc-103498. Western blot analysis of FNBP2 expression in non-transfected: sc-117752 (A) and mouse FNBP2 transfected: sc-178625 (B) 293T whole cell lysates.

Anti-srGAP2 antibody - ab121977 from Abcam

Prices	$443.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab121977 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Anti-srGAP2 antibody - ab121976 from Abcam

Prices	$443.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunofluorescent staining of Human cell line U-2 OS shows positivity in cytoplasm. Recommended concentration of ab121976 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Anti-srGAP2 antibody [EP2506(2)] - ab124958 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2506(2)

All lanes : Anti-srGAP2 antibody [EP2506(2)] (ab124958) at 1/1000 dilutionLane 1 : Mouse brain lysates Lane 2 : SH SY5Y lysates Lane 3 : 293T lysates Lane 4 : JAR lysates Lysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-Rabbit IgG at 1/2000 dilution

Anti-SRGAP2 Antibody (Internal, clone EP2506(2)) - LS-C138634 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2506(2)

Western blot analysis on (A) mouse brain, (B) SH-SY5Y, (C) 293T, and (D) JAR lysates using anti-srGAP2 antibody.

Anti-SRGAP2 Antibody (aa197-210) - LS-C139575 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

SRGAP2 antibody (0.1 ug/ml) staining of Rat Cortical Neuron lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

SRGAP2 Antibody - NBP1-89013 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SRGAP3 Antibody - NBP1-88831 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: SRGAP3 Antibody [NBP1-88831] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: Cerebral Cortex

SRGAP2 Antibody - NBP1-88830 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: SRGAP2 Antibody [NBP1-88830] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10Lane 2: Human cell line SK-MEL-30

SRGAP2 Antibody - NBP1-49877 from Novus Biologicals

Prices	$299.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Western Blot: SRGAP2 Antibody [NBP1-49877] - (0.1ug/ml) staining of Rat Cortical Neuron lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Data kindly provided by Ms. Ya-Jing Mi and Dr.Wei-Lin Jin, Institute of Neurosciences, Shanghai Jiao Tong Univer

SRGAP2 Antibody - 45340002 from Novus Biologicals

Prices	$299.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SRGAP2 antibody produced in rabbit - HPA028196 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-SRGAP2: <B>Cat. No. HPA028196</B>: Immunohistochemical staining of human adrenal gland shows strong cytoplasmic and nuclear positivity in cortical cells.

Anti-SRGAP2 antibody produced in goat - SAB2501399 from Sigma-Aldrich

Prices	$376.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Anti-SRGAP2 <B>Cat. No. SAB2501399</B>: (0.1 μg/mL) staining of Rat Cortical Neuron lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SRGAP2 antibody produced in rabbit - HPA028191 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-SRGAP2: <B>Cat. No. HPA028191</B>: Immunohistochemical staining of human duodenum shows strong membranous positivity in glandular cells.

SRGAP3 Antibody - N-terminal region (ARP65106_P050) - ARP65106_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SRGP2 Antibody - N-terminal region (ARP75473_P050) - ARP75473_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

SRGAP2-Antibody-internal-region - AF3077a from Abgent, a WuXi AppTec company

Prices	$335.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

AF3077a (0.1 µg/ml) staining of Rat Cortical Neuron lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Data kindly provided by Ms. Ya-Jing Mi and Dr.Wei-Lin Jin, Institute of Neurosciences, Shanghai Jiao Tong University.

SRGAP2 Antibody (OAEB00824) - OAEB00824 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

SRGAP3 antibody - 70R-20519 from Fitzgerald

Prices	$375.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

ARHGAP34 / SRGAP2 antibody - 22519-1-AP from Acris Antibodies

Prices	$270.00
Sizes	150 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of paraffin-embedded human kidney slide using 22519-1-AP( SRGAP2 Antibody) at dilution of 1:50

ARHGAP34 / SRGAP2 antibody - AP22442PU-N from Acris Antibodies

Prices	$310.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-SRGAP2 Antibody - AC21-2068 from Abcore

Prices	$359.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-SRGAP2 Antibody (AMCA) - AC21-2068-01 from Abcore

Prices	$495.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

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