VPS39

Gene Symbol VPS39
Entrez Gene 23339
Alt Symbol TLP, VAM6, hVam6p
Species Human
Gene Type protein-coding
Description vacuolar protein sorting 39 homolog (S. cerevisiae)
Other Description TRAP1-like protein|vam6/Vps39-like protein
Swissprots Q96B93 Q96RM0 Q7Z3V3 Q71SQ6 O94869 Q96JC1
Accessions AAK58862 EAW92535 EAW92536 EAW92537 EAW92538 EAW92539 Q96JC1 AB018313 BAA34490 AF280814 AAK72222 AF281052 AAQ05978 AK025334 AK074193 AK124255 AK128403 BAG54672 AL117456 AM392538 CAL37416 AM393769 CAL38644 BC015817 AAH15817 BC068559 AAH68559 BX537404 CAD97646 DB461120 XM_011521403 XP_011519705 XM_011521404 XP_011519706 XM_011521405 XP_011519707 XM_011521406 XP_011519708 NM_001301138 NP_001288067 NM_015289 NP_056104
Function May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:12941698}.
Subcellular Location Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles.
Tissue Specificity Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen. {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:12941698}.

VPS39 (D-15) - sc-104759 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VPS39 (D-15): sc-104759. Western blot analysis of VPS39 expression in MIA PaCa-2 whole cell lysate.

VPS39 (H-300) - sc-367368 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
VPS39 (H-300): sc-367368. Western blot analysis of VPS39 expression in MIA PaCa-2 (A) and NTERA-2 cl.D1 (B) whole cell lysates.

VPS39 (S-14) - sc-104761 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VPS39 (S-14): sc-104761. Western blot analysis of VPS39 expression in mouse heart tissue extract.

Anti-VPS39 antibody - ab107570 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of VPS39 in mouse liver tissue with ab107570 at 20 ug/mL.

Anti-VPS39 antibody - ab90516 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-VPS39 antibody - ab69669 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-VPS39 antibody (ab69669) at 1/500 dilutionLane 1 : VPS39 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

Anti-VPS39 Antibody (Internal) - LS-C145092 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-VPS39 Antibody (C-Terminus) IHC-plus™ - LS-B7035 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-VPS39 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7035 concentration 5 ug/ml.

VPS39 Antibody - NBP1-76535 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: VPS39 Antibody [NBP1-76535] - Rat liver tissue lysate with VPS39 antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.

VPS39 Antibody - NBP2-32055 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: VPS39 Antibody [NBP2-32055] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

VPS39 Antibody - H00023339-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

VPS39 Antibody - H00023339-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

VPS39 Antibody - H00023339-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VPS39 antibody produced in mouse - SAB1407200 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-VPS39: <B>Cat. No. SAB1407200</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~96.3 kDa using VPS39 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-VPS39 antibody produced in rabbit - SAB1410418 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-VPS39: <B>Cat. No. SAB1410418</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~100.8 kDa using VPS39 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

VPS39 antibody - orb75569 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat liver tissue lysate at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide using VPS39 antibody

VPS39 antibody - orb155366 from Biorbyt

Prices $425.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

VPS39 Antibody - abx037041 from Abbexa

Host Rabbit
Clonality Polyclonal

VPS39 pSer39 antibody - 16219-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal

VPS39 (C-term) antibody - AP26102PU-N from Acris Antibodies

Prices $340.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of VPS39 in rat liver tissue lysate with VPS39 antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.

VPS39 pSer39 antibody - AP55373SU-N from Acris Antibodies

Prices $460.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

VPS39 antibody - H00023339-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot analysis of VPS39 expression in transfected 293T cell line (H00023339-T01) by VPS39 MaxPab polyclonal antibody. Lane1:VPS39 transfected lysate(96.25 KDa). Lane2:Non-transfected lysate.

VPS39 antibody - H00023339-D01 from Acris Antibodies

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

VPS39 antibody - H00023339-D01P from Acris Antibodies

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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