VPS39

Gene Symbol VPS39
Entrez Gene 23339
Alt Symbol TLP, VAM6, hVam6p
Species Human
Gene Type protein-coding
Description vacuolar protein sorting 39 homolog (S. cerevisiae)
Other Description TRAP1-like protein|vam6/Vps39-like protein
Swissprots Q96B93 Q96RM0 Q7Z3V3 Q71SQ6 O94869 Q96JC1
Accessions AAK58862 EAW92535 EAW92536 EAW92537 EAW92538 EAW92539 Q96JC1 AB018313 BAA34490 AF280814 AAK72222 AF281052 AAQ05978 AK025334 AK074193 AK124255 AK128403 BAG54672 AL117456 AM392538 CAL37416 AM393769 CAL38644 BC015817 AAH15817 BC068559 AAH68559 BX537404 CAD97646 DB461120 XM_011521403 XP_011519705 XM_011521404 XP_011519706 XM_011521405 XP_011519707 XM_011521406 XP_011519708 NM_001301138 NP_001288067 NM_015289 NP_056104
Function May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:12941698}.
Subcellular Location Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles.
Tissue Specificity Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen. {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:12941698}.

VPS39 CRISPR/Cas9 KO Plasmid (h) - sc-404507 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS39 HDR Plasmid (h) - sc-404507-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS39 Double Nickase Plasmid (h) - sc-404507-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS39 Double Nickase Plasmid (h2) - sc-404507-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS39 CRISPR Activation Plasmid (h) - sc-404507-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS39 CRISPR Activation Plasmid (h2) - sc-404507-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS39 Lentiviral Activation Particles (h) - sc-404507-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS39 Lentiviral Activation Particles (h2) - sc-404507-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS39 siRNA (h) - sc-90114 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VPS39 shRNA Plasmid (h) - sc-90114-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VPS39 shRNA (h) Lentiviral Particles - sc-90114-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU066081 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22725 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22725 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10807 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10807

VPS39 siRNA (Human) - CRH8193 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VPS39 - MBS8237030 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human VPS39 (NM_015289.2) - SHH445024 from Creative biogene

Category siRNA
Species Reactivities Human

Human VPS39 siRNA - orb268695 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VPS39 shRNA Plasmid (Human) - CHH8193 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

VPS39 miRNA 3'UTR clone - MiUTR1H-11156 from Creative biogene

Species Reactivities Human
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