VPS39

Gene Symbol	VPS39
Entrez Gene	23339
Alt Symbol	TLP, VAM6, hVam6p
Species	Human
Gene Type	protein-coding
Description	vacuolar protein sorting 39 homolog (S. cerevisiae)
Other Description	TRAP1-like protein|vam6/Vps39-like protein
Swissprots	Q96B93 Q96RM0 Q7Z3V3 Q71SQ6 O94869 Q96JC1
Accessions	AAK58862 EAW92535 EAW92536 EAW92537 EAW92538 EAW92539 Q96JC1 AB018313 BAA34490 AF280814 AAK72222 AF281052 AAQ05978 AK025334 AK074193 AK124255 AK128403 BAG54672 AL117456 AM392538 CAL37416 AM393769 CAL38644 BC015817 AAH15817 BC068559 AAH68559 BX537404 CAD97646 DB461120 XM_011521403 XP_011519705 XM_011521404 XP_011519706 XM_011521405 XP_011519707 XM_011521406 XP_011519708 NM_001301138 NP_001288067 NM_015289 NP_056104
Function	May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:12941698}.
Subcellular Location	Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles.
Tissue Specificity	Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen. {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:12941698}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VPS39 full length protein - ab161608 from Abcam Category Protein Source Wheat germ Species Human

VPS39 Antibody Blocking Peptide - LS-E31077 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human VPS39 Protein - H00023339-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

VPS39 Blocking Peptide - NBP1-76535PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

VPS39-Antibody-Center-Blocking-Peptide - BP17455c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VPS39 - H00023339-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

VPS39 control peptide - AP26102CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

VPS39 Peptide - 6183P from ProSci Category Peptide Species Human

VPS39 fusion protein - Ag9158 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

VPS39 fusion protein - Ag9267 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human VPS39, His-tagged - VPS39-3681H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Vam6/Vps39-like protein(VPS39) ,partial - CSB-YP836235HU CSB-EP836235HU CSB-BP836235HU CSB-MP836235HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Pongo abelii TATA box-binding protein-like protein 1(TBPL1) - CSB-YP712872PYX CSB-EP712872PYX CSB-BP712872PYX CSB-MP712872PYX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Orangutan

VPS39 - TP309854 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Vam6/Vps39-like protein(VPS39) ,partial, Recombinant Protein - MBS1399542 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

VPS39 Protein - NBP2-32055PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

VPS39 Peptide, Human - M34GP17322H from Creative Peptides Category Peptide Source Synthetic. Species Human

Search more