| Gene Symbol |
ABCC2
|
| Entrez Gene |
1244
|
| Alt Symbol |
ABC30, CMOAT, DJS, MRP2, cMRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
|
| Other Description |
canalicular multidrug resistance protein|canalicular multispecific organic anion transporter 1|multidrug resistance-associated protein 2
|
| Swissprots |
B2RMT8 Q92798 Q92500 Q5T2B1 Q14022 Q99663 Q9UMS2 Q92887
|
| Accessions |
AAD47599 CAB45309 CAJ33679 CAS97349 EAW49852 EAW49853 Q92887 BC136419 AAI36420 BM765259 CB120555 U49248 AAB09422 U63970 AAB39892 U66683 X96395 CAA65259 XM_006717630 XP_006717693 XM_006717631 XP_006717694 XM_011539291 XP_011537593 XR_945604 XR_945605 NM_000392 NP_000383
|
| Function |
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
|
| Subcellular Location |
Apical cell membrane {ECO:0000269|PubMed:11093739}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:11093739}.
|
| Tissue Specificity |
Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.
|
| Top Pathways |
ABC transporters, Bile secretion
|