| Gene Symbol |
Ube2c
|
| Entrez Gene |
68612
|
| Alt Symbol |
1110015A16Rik, D2Ertd695e
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2C
|
| Other Description |
ubcH10|ubiquitin carrier protein C|ubiquitin-conjugating enzyme E2 C|ubiquitin-protein ligase C
|
| Swissprots |
Q3TUJ0 Q9D1C1
|
| Accessions |
EDL06414 Q9D1C1 AK003722 BAB22959 AK136186 BAE22863 AK160740 BAE35981 BC147032 AAI47033 BC147033 AAI47034 BC171983 NM_026785 NP_081061
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity). {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|