| Gene Symbol | Ube2c |
|---|---|
| Entrez Gene | 68612 |
| Alt Symbol | 1110015A16Rik, D2Ertd695e |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ubiquitin-conjugating enzyme E2C |
| Other Description | ubcH10|ubiquitin carrier protein C|ubiquitin-conjugating enzyme E2 C|ubiquitin-protein ligase C |
| Swissprots | Q3TUJ0 Q9D1C1 |
| Accessions | EDL06414 Q9D1C1 AK003722 BAB22959 AK136186 BAE22863 AK160740 BAE35981 BC147032 AAI47033 BC147033 AAI47034 BC171983 NM_026785 NP_081061 |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity). {ECO:0000250}. |
| Top Pathways | Ubiquitin mediated proteolysis |