Gene Symbol | Ube2c |
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Entrez Gene | 68612 |
Alt Symbol | 1110015A16Rik, D2Ertd695e |
Species | Mouse |
Gene Type | protein-coding |
Description | ubiquitin-conjugating enzyme E2C |
Other Description | ubcH10|ubiquitin carrier protein C|ubiquitin-conjugating enzyme E2 C|ubiquitin-protein ligase C |
Swissprots | Q3TUJ0 Q9D1C1 |
Accessions | EDL06414 Q9D1C1 AK003722 BAB22959 AK136186 BAE22863 AK160740 BAE35981 BC147032 AAI47033 BC147033 AAI47034 BC171983 NM_026785 NP_081061 |
Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity). {ECO:0000250}. |
Top Pathways | Ubiquitin mediated proteolysis |
UBE2C CRISPR/Cas9 KO Plasmid (m) - sc-427115 from Santa Cruz Biotechnology
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UBE2C HDR Plasmid (m) - sc-427115-HDR from Santa Cruz Biotechnology
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UBE2C Double Nickase Plasmid (m) - sc-427115-NIC from Santa Cruz Biotechnology
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UBE2C Double Nickase Plasmid (m2) - sc-427115-NIC-2 from Santa Cruz Biotechnology
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UBE2C CRISPR Activation Plasmid (m) - sc-427115-ACT from Santa Cruz Biotechnology
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UBE2C CRISPR Activation Plasmid (m2) - sc-427115-ACT-2 from Santa Cruz Biotechnology
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UBE2C Lentiviral Activation Particles (m) - sc-427115-LAC from Santa Cruz Biotechnology
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UBE2C Lentiviral Activation Particles (m2) - sc-427115-LAC-2 from Santa Cruz Biotechnology
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UBE2C siRNA (m) - sc-61743 from Santa Cruz Biotechnology
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UBE2C shRNA Plasmid (m) - sc-61743-SH from Santa Cruz Biotechnology
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UBE2C shRNA (m) Lentiviral Particles - sc-61743-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN43799 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43799 from Sigma-Aldrich
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UBE2C siRNA (Mouse) - CRM7705 from Cohesion Biosciences
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UBE2C - MBS8206576 from MyBioSource
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shRNA set against Mouse UBE2C (NM_026785.2) - SHH438860 from Creative biogene
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shRNA set against Mouse Ube2c(NM_026785.2) - SHL110316 from Creative biogene
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Mouse UBE2C siRNA - orb287181 from Biorbyt
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UBE2C shRNA Plasmid (Mouse) - CHM7705 from Cohesion Biosciences
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UBE2C miRNA 3'UTR clone - MiUTR1M-12378 from Creative biogene
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