| Gene Symbol | GOT2 |
|---|---|
| Entrez Gene | 2806 |
| Alt Symbol | KAT4, KATIV, mitAAT |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamic-oxaloacetic transaminase 2, mitochondrial |
| Other Description | FABP-1|FABPpm|aspartate aminotransferase 2|aspartate aminotransferase, mitochondrial|aspartate transaminase 2|fatty acid-binding protein|glutamate oxaloacetate transaminase 2|glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)|kynurenine aminotransferase 4|kynurenine aminotransferase IV|kynurenine--oxoglutarate transaminase 4|kynurenine--oxoglutarate transaminase IV|mAspAT|plasma membrane-associated fatty acid-binding protein|transaminase A |
| Swissprots | Q53FL3 Q9BWA3 E7ERW2 B4DJA6 P00505 |
| Accessions | EAW82988 EAW82989 P00505 AK098313 BAG53610 AK223271 BAD96991 AK290847 BAF83536 AK295993 BAG58768 AK302249 BAG63601 AK307598 AL516773 BC000525 AAH00525 BI667777 DB485399 DQ891883 ABM82809 DQ895068 ABM85994 M22632 AAA35568 NM_001286220 NP_001273149 NM_002080 NP_002071 |
| Function | Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:9537447}. |
| Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}. Note=Exposure to alcohol promotes translocation to the cell membrane. |
| Top Pathways | Cysteine and methionine metabolism, Fat digestion and absorption, Alanine, aspartate and glutamate metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism |