GOT2

Gene Symbol GOT2
Entrez Gene 2806
Alt Symbol KAT4, KATIV, mitAAT
Species Human
Gene Type protein-coding
Description glutamic-oxaloacetic transaminase 2, mitochondrial
Other Description FABP-1|FABPpm|aspartate aminotransferase 2|aspartate aminotransferase, mitochondrial|aspartate transaminase 2|fatty acid-binding protein|glutamate oxaloacetate transaminase 2|glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)|kynurenine aminotransferase 4|kynurenine aminotransferase IV|kynurenine--oxoglutarate transaminase 4|kynurenine--oxoglutarate transaminase IV|mAspAT|plasma membrane-associated fatty acid-binding protein|transaminase A
Swissprots Q53FL3 Q9BWA3 E7ERW2 B4DJA6 P00505
Accessions EAW82988 EAW82989 P00505 AK098313 BAG53610 AK223271 BAD96991 AK290847 BAF83536 AK295993 BAG58768 AK302249 BAG63601 AK307598 AL516773 BC000525 AAH00525 BI667777 DB485399 DQ891883 ABM82809 DQ895068 ABM85994 M22632 AAA35568 NM_001286220 NP_001273149 NM_002080 NP_002071
Function Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:9537447}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}. Note=Exposure to alcohol promotes translocation to the cell membrane.
Top Pathways Cysteine and methionine metabolism, Fat digestion and absorption, Alanine, aspartate and glutamate metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism

AATM (E-7) - sc-271702 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AATM (E-7): sc-271702. Western blot analysis of AATM expression in rat brain tissue extract (A) and HEK293 whole cell lysate (B).

AATM (C-21) - sc-46704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AATM (C-21): sc-46704. Western blot analysis of AATM expression in Hep G2 whole cell lysate (A) and rat brain tissue extract (B).

AATM (V-15) - sc-46707 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AATM (V-15): sc-46707. Western blot analysis of AATM expression in Hep G2 whole cell lysate.

Anti-GOT2 antibody - ab153924 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GOT2 antibody (ab153924) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-GOT2 antibody - ab64893 from Abcam

Prices $378.00
Sizes 50 µl
Host Sheep
Clonality Polyclonal
This image shows skeletal muscle stained with ab64893 at 20µg/ml.

Anti-GOT2 antibody - ab184012 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GOT2 antibody (ab184012) at 1/10000 dilutionLane 1 : NIH-3T3Lane 2 : JCLane 3 : BCL-1Lane 4 : C2C12Lane 5 : Raw264.7Lysates/proteins at 30 µg per lane.

Anti-GOT2 antibody - ab90562 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-GOT2 antibody (ab90562) at 1 µg/ml + Recombinant protein at 0.2 µgdeveloped using the ECL technique

Anti-GOT2 antibody [13] - ab80223 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 13
Overlay histogram showing HepG2 cells stained with ab80223 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab80223, 0.01μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-GOT2 antibody [14] - ab95387 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 14
Anti-GOT2 antibody [14] (ab95387) at 1/1000 dilution + HepG2 whole cell lysate

Anti-GOT2 antibody [3E9] - ab93928 from Abcam

Host Mouse
Clonality Monoclonal
Clone 3E9
All lanes : Anti-GOT2 antibody [3E9] (ab93928) at 1/500 dilutionLane 1 : HEK293 cell lysateLane 2 : PC-12 cell lysateLane 3 : HL-60 cell lysateLane 4 : BCBL-1 cell lysateLane 5 : HepG2 cell lysateLane 6 : NIH/3T3 cell lysate

Anti-GOT2 antibody [EPR12354(B)] - ab171739 from Abcam

Prices $388.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12354(B)
Flow cytometric analysis of permeabilized 293T cells labeling GOT2 using ab171739 at 1/100 (red) or a rabbit IgG (negative) (green).

Anti-GOT2 antibody [EPR12355(B)] - ab180162 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12355(B)
All lanes : Anti-GOT2 antibody [EPR12355(B)] (ab180162) at 1/5000 dilutionLane 1 : Fetal liver cell lysateLane 2 : 293T cell lysateLane 3 : HepG2 cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.developed using the ECL technique

Anti-GOT2 antibody - N-terminal - ab135741 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GOT2 antibody - N-terminal (ab135741) at 1/100 dilutionLane 1 : HeLa cell line lysatesLane 2 : HepG2 cell line lysatesLane 3 : HL60 cell line lysatesLane 4 : Ramos cell line lysatesLysates/proteins at 35 µg per lane.

Anti-GOT2 Antibody (aa295-306) IHC-plus™ - LS-B2454 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-GOT2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2454 concentration 5 ug/ml.

Anti-GOT2 Antibody (clone 3E9) IHC-plus™ - LS-B3906 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 3E9
Anti-GOT2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3906 dilution 1:200.

Anti-GOT2 Antibody (aa36-85) IHC-plus™ - LS-B11927 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-GOT2 Antibody - LS-C59320 from LifeSpan Bioscience

Prices $395.00
Sizes 2 ml
Host Sheep
Clonality Polyclonal

Anti-GOT2 Antibody (HRP) - LS-C183198 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GOT2 Antibody (FITC) - LS-C183199 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GOT2 Antibody (Biotin) - LS-C183200 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GOT2 Antibody (aa25-430) - LS-C137545 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-GOT2 Antibody (aa25-430) - LS-C137544 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-GOT2 Antibody (aa33-61, APC) - LS-C277657 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GOT2 Antibody (aa33-61, AP) - LS-C277656 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GOT2 Antibody (aa40-89) - LS-C80577 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.
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