Gene Symbol | GOT2 |
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Entrez Gene | 2806 |
Alt Symbol | KAT4, KATIV, mitAAT |
Species | Human |
Gene Type | protein-coding |
Description | glutamic-oxaloacetic transaminase 2, mitochondrial |
Other Description | FABP-1|FABPpm|aspartate aminotransferase 2|aspartate aminotransferase, mitochondrial|aspartate transaminase 2|fatty acid-binding protein|glutamate oxaloacetate transaminase 2|glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)|kynurenine aminotransferase 4|kynurenine aminotransferase IV|kynurenine--oxoglutarate transaminase 4|kynurenine--oxoglutarate transaminase IV|mAspAT|plasma membrane-associated fatty acid-binding protein|transaminase A |
Swissprots | Q53FL3 Q9BWA3 E7ERW2 B4DJA6 P00505 |
Accessions | EAW82988 EAW82989 P00505 AK098313 BAG53610 AK223271 BAD96991 AK290847 BAF83536 AK295993 BAG58768 AK302249 BAG63601 AK307598 AL516773 BC000525 AAH00525 BI667777 DB485399 DQ891883 ABM82809 DQ895068 ABM85994 M22632 AAA35568 NM_001286220 NP_001273149 NM_002080 NP_002071 |
Function | Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. {ECO:0000269|PubMed:9537447}. |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}. Note=Exposure to alcohol promotes translocation to the cell membrane. |
Top Pathways | Cysteine and methionine metabolism, Fat digestion and absorption, Alanine, aspartate and glutamate metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism |
GOT2 peptide - ab170417 from Abcam
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GOT2 peptide - ab170593 from Abcam
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Human GOT2 full length protein - ab140064 from Abcam
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Human GOT2 protein fragment - ab170592 from Abcam
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GOT2 Antibody Blocking Peptide - LS-E16012 from LifeSpan Bioscience
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GOT2 Antibody Blocking Peptide - LS-E26530 from LifeSpan Bioscience
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GOT2 Antibody Blocking Peptide - LS-E26589 from LifeSpan Bioscience
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GOT2 Antibody Blocking Peptide - LS-E9878 from LifeSpan Bioscience
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GOT2 Partial Recombinant Protein - H00002806-Q01 from Novus Biologicals
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GOT2 Recombinant Protein - H00002806-P01 from Novus Biologicals
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Recombinant Human GOT2 Protein - NBP2-23078 from Novus Biologicals
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GOT2-Antibody-N-term-Blocking-Peptide - BP8968a from Abgent, a WuXi AppTec company
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GOT2 (aa 295 to 306) blocking peptide - GTX88853-PEP from GeneTex
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GOT2 (aa 360 to 373) blocking peptide - GTX88925-PEP from GeneTex
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Recombinant human Aspartate aminotransferase, mitochondrial (OPCA00490) - OPCA00490 from Aviva Systems Biology
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Fatty Acid Binding Protein (OPMA04344) - OPMA04344 from Aviva Systems Biology
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Human GOT2 protein - orb168422 from Biorbyt
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Human GOT2 protein - orb246678 from Biorbyt
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FABP1 protein - 30R-2618 from Fitzgerald
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GOT2 Blocking Peptide - 33R-7247 from Fitzgerald
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GOT2 Blocking Peptide - 33R-1275 from Fitzgerald
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GOT2 Blocking Peptide - 33R-9504 from Fitzgerald
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GOT2 protein - 30R-3126 from Fitzgerald
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GOT2 protein - 30R-3177 from Fitzgerald
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GOT2 protein (His tag) - 80R-2647 from Fitzgerald
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