| Gene Symbol |
UGT2B28
|
| Entrez Gene |
54490
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 2 family, polypeptide B28
|
| Other Description |
UDP glycosyltransferase 2 family, polypeptide B28|UDP-glucuronosyltransferase 2B28|UDPGT 2B28
|
| Swissprots |
Q9BY62 Q9BY64 B5BUM0 Q9BY63
|
| Accessions |
EAX05588 EAX05589 EAX05590 Q9BY64 AB451456 BAG70270 AF177272 AAK31807 AF177273 AAK31808 AF177274 AAK31809 BC156172 AAI56173 BC157011 AAI57012 XM_011532036 XP_011530338 NM_001207004 NP_001193933 NM_053039 NP_444267
|
| Function |
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active. {ECO:0000269|PubMed:11300766}.
|
| Subcellular Location |
Microsome membrane {ECO:0000269|PubMed:11300766}; Single-pass membrane protein {ECO:0000269|PubMed:11300766}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11300766}; Single-pass membrane protein {ECO:0000269|PubMed:11300766}.
|
| Tissue Specificity |
Expressed in the liver, breast and kidney. {ECO:0000269|PubMed:11300766}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|