Gene Symbol | UGT2B28 |
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Entrez Gene | 54490 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | UDP glucuronosyltransferase 2 family, polypeptide B28 |
Other Description | UDP glycosyltransferase 2 family, polypeptide B28|UDP-glucuronosyltransferase 2B28|UDPGT 2B28 |
Swissprots | Q9BY62 Q9BY64 B5BUM0 Q9BY63 |
Accessions | EAX05588 EAX05589 EAX05590 Q9BY64 AB451456 BAG70270 AF177272 AAK31807 AF177273 AAK31808 AF177274 AAK31809 BC156172 AAI56173 BC157011 AAI57012 XM_011532036 XP_011530338 NM_001207004 NP_001193933 NM_053039 NP_444267 |
Function | UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active. {ECO:0000269|PubMed:11300766}. |
Subcellular Location | Microsome membrane {ECO:0000269|PubMed:11300766}; Single-pass membrane protein {ECO:0000269|PubMed:11300766}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11300766}; Single-pass membrane protein {ECO:0000269|PubMed:11300766}. |
Tissue Specificity | Expressed in the liver, breast and kidney. {ECO:0000269|PubMed:11300766}. |
Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450 |
UGT2B28 CRISPR/Cas9 KO Plasmid (h) - sc-404211 from Santa Cruz Biotechnology
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UGT2B28 HDR Plasmid (h) - sc-404211-HDR from Santa Cruz Biotechnology
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UGT2B28 Double Nickase Plasmid (h) - sc-404211-NIC from Santa Cruz Biotechnology
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UGT2B28 Double Nickase Plasmid (h2) - sc-404211-NIC-2 from Santa Cruz Biotechnology
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UGT2B28 CRISPR Activation Plasmid (h) - sc-404211-ACT from Santa Cruz Biotechnology
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UGT2B28 CRISPR Activation Plasmid (h2) - sc-404211-ACT-2 from Santa Cruz Biotechnology
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UGT2B28 Lentiviral Activation Particles (h) - sc-404211-LAC from Santa Cruz Biotechnology
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UGT2B28 Lentiviral Activation Particles (h2) - sc-404211-LAC-2 from Santa Cruz Biotechnology
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UGT2B28 siRNA (h) - sc-106669 from Santa Cruz Biotechnology
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UGT2B28 shRNA Plasmid (h) - sc-106669-SH from Santa Cruz Biotechnology
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UGT2B28 shRNA (h) Lentiviral Particles - sc-106669-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU128051 from Sigma-Aldrich
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MISSION® esiRNA - EHU105221 from Sigma-Aldrich
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MISSION® esiRNA - EHU105501 from Sigma-Aldrich
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MISSION® esiRNA - EHU038411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22471 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01623 from Sigma-Aldrich
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UGT2B28 siRNA (Human) - CRJ0089 from Cohesion Biosciences
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UGT2B28 - MBS8228589 from MyBioSource
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shRNA set against Human UGT2B28 (NM_053039.1) - SHH440200 from Creative biogene
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Human UGT2B28 siRNA - orb270590 from Biorbyt
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UGT2B28 shRNA Plasmid (Human) - CHJ0089 from Cohesion Biosciences
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UGT2B28 miRNA 3'UTR clone - MiUTR1H-10997 from Creative biogene
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