Aifm1
| Gene Symbol | Aifm1 |
|---|---|
| Entrez Gene | 26926 |
| Alt Symbol | AIF, AIFsh2, Hq, Pdcd8 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | apoptosis-inducing factor, mitochondrion-associated 1 |
| Other Description | apoptosis-inducing factor 1, mitochondrial|harlequin|programmed cell death protein 8 |
| Swissprots | Q9Z0X1 |
| Accessions | EDL29077 Q9Z0X1 AA261021 AF100927 AAD16435 AK133764 AK165762 AK180729 AK211178 AK211196 AK219625 BC003292 AAH03292 BC024882 BY250260 DQ016499 AAY84740 NM_001290364 NP_001277293 NM_012019 NP_036149 |
| Function | Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis,and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion intermembrane space {ECO:0000269|PubMed:9989411}. Mitochondrion inner membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000269|PubMed:9989411}. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region (By similarity). {ECO:0000250}. |
| Top Pathways | Apoptosis |
Apoptosis-inducing factor 1, mitochondrial, Aifm1, Mouse, ELISA Kit - E1064m from ARP American Research Products
|
||||||||||
Mouse AIF ELISA Kit - MA0535 from NeoScientific
|
||||||||||
Mouse AIF(Apoptosis Inducing Factor) ELISA Kit - E-EL-M0141 from Elabscience
|
||||||||||
Mouse AIF (Apoptosis Inducing Factor) CLIA Kit - E-CL-M0104 from Elabscience
|
||||||||||
Mouse Apoptosis Inducing Factor ELISA - E03A0528 from BlueGene Biotech
|
||||||||||
Mouse AIF(Apoptosis Inducing Factor) ELISA Kit - E-EL-M0141 from Iwai North America Inc.
|
||||||||||
Mouse AIF (Apoptosis Inducing Factor) CLIA Kit - E-CL-M0104 from Iwai North America Inc.
|
||||||||||
Mouse Apoptosis-inducing factor 1, mitochondrial ELISA Kit - EKE51838 from Biomatik
|
||||||||||
AIF - EKM1652 from Nordic BioSite
|
||||||||||
Mouse AIF ELISA Kit - E043113 from Biobool
|
||||||||||
Mouse Aifm1 ELISA Kit - E044669 from Biobool
|
||||||||||
AIFM1 ELISA Kit (Mouse) (OKEH04428) - OKEH04428 from Aviva Systems Biology
|
||||||||||
Mouse AIF ELISA Kit - EMA0535 from ABclonal
|
||||||||||
Apoptosis Inducing Factor (AIF), ELISA Kit - MBS453735 from MyBioSource
|