| Gene Symbol |
Aifm1
|
| Entrez Gene |
26926
|
| Alt Symbol |
AIF, AIFsh2, Hq, Pdcd8
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
apoptosis-inducing factor, mitochondrion-associated 1
|
| Other Description |
apoptosis-inducing factor 1, mitochondrial|harlequin|programmed cell death protein 8
|
| Swissprots |
Q9Z0X1
|
| Accessions |
EDL29077 Q9Z0X1 AA261021 AF100927 AAD16435 AK133764 AK165762 AK180729 AK211178 AK211196 AK219625 BC003292 AAH03292 BC024882 BY250260 DQ016499 AAY84740 NM_001290364 NP_001277293 NM_012019 NP_036149
|
| Function |
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis,and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion intermembrane space {ECO:0000269|PubMed:9989411}. Mitochondrion inner membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000269|PubMed:9989411}. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region (By similarity). {ECO:0000250}.
|
| Top Pathways |
Apoptosis
|