SPRTN

Gene Symbol	SPRTN
Entrez Gene	83932
Alt Symbol	C1orf124, DVC1, PRO4323, spartan
Species	Human
Gene Type	protein-coding
Description	SprT-like N-terminal domain
Other Description	DNA damage protein targeting VCP|DNA damage-targeting VCP (p97) adaptor|sprT-like domain-containing protein Spartan|zinc finger RAD18 domain-containing protein
Swissprots	Q6UWW6 Q9H040 Q96KA0 Q5TE78 B5MEF7 B1AKT0 Q96BC5
Accessions	CCQ43030 CCQ43757 EAW69956 EAW69957 EAW69958 Q9H040 AK027317 BAB55037 AK027613 BAB55232 AL512744 CAC21670 AM393399 CAL38277 AM393461 CAL38338 AM393630 CAL38506 AY358611 AAQ88974 BC015740 AAH15740 BC068478 AAH68478 BM480135 BU630543 XM_005273284 XP_005273341 XM_005273285 XP_005273342 XM_006711818 XP_006711881 XM_011544288 XP_011542590 XM_011544289 XP_011542591 NM_001010984 NP_001010984 NM_001261462 NP_001248391 NM_032018 NP_114407
Function	Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. {ECO:0000269|PubMed:22681887, ECO:0000269|PubMed:22894931, ECO:0000269|PubMed:22902628, ECO:0000269|PubMed:22987070, ECO:0000269|PubMed:23042605, ECO:0000269|PubMed:23042607}.
Subcellular Location	Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled relication forks at sites of replication stress.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Spartan (N-18) - sc-240086 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Spartan (S-20) - sc-240087 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-C1orf124 antibody - ab121853 from Abcam Prices $443.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-C1orf124 antibody - ab167190 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-C1orf124 antibody - C-terminal - ab177923 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SPRTN / C1orf124 Antibody (C-Terminus) - LS-C186903 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SPRTN / C1orf124 Antibody (aa186-235) - LS-C170619 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

C1orf124 Antibody - NBP1-84163 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody - bs-15013R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-15013R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-15013R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-15013R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-15013R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, Cy3 Conjugated - bs-15013R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, Cy5 Conjugated - bs-15013R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, Cy5.5 Conjugated - bs-15013R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, Cy7 Conjugated - bs-15013R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, FITC Conjugated - bs-15013R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, Biotin Conjugated - bs-15013R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 Polyclonal Antibody, HRP Conjugated - bs-15013R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-C1orf124 antibody produced in mouse - SAB1409875 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-SPRTN antibody produced in rabbit - HPA025073 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SPRTN Antibody - C-terminal region (ARP68994_P050) - ARP68994_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SPRTN Antibody - middle region (ARP68995_P050) - ARP68995_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

C1orf124 antibody [N1N3] - GTX116937 from GeneTex Host Rabbit Clonality Polyclonal

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