| Gene Symbol |
SLC2A4
|
| Entrez Gene |
6517
|
| Alt Symbol |
GLUT4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 2 (facilitated glucose transporter), member 4
|
| Other Description |
GLUT-4|glucose transporter type 4, insulin-responsive|insulin-responsive glucose transporter type 4|solute carrier family 2, facilitated glucose transporter member 4
|
| Swissprots |
Q05BQ3 P14672 Q14CX2
|
| Accessions |
AAA52569 CAA41399 EAW90226 EAW90227 P14672 AK300899 BAG62537 AK313372 BAG36171 AL521328 BC034387 AAH34387 BC069615 AAH69615 BC069621 AAH69621 BC113592 AAI13593 BC126164 AAI26165 BQ775137 CF594356 HQ258267 ADR83021 M20747 AAA59189 NM_001042 NP_001033
|
| Function |
Insulin-regulated facilitative glucose transporter.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endomembrane system {ECO:0000269|PubMed:8300557}; Multi-pass membrane protein {ECO:0000269|PubMed:8300557}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8300557}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.
|
| Tissue Specificity |
Skeletal and cardiac muscles; brown and white fat.
|
| Top Pathways |
Insulin signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, AMPK signaling pathway
|