Gene Symbol | SLC2A4 |
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Entrez Gene | 6517 |
Alt Symbol | GLUT4 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 2 (facilitated glucose transporter), member 4 |
Other Description | GLUT-4|glucose transporter type 4, insulin-responsive|insulin-responsive glucose transporter type 4|solute carrier family 2, facilitated glucose transporter member 4 |
Swissprots | Q05BQ3 P14672 Q14CX2 |
Accessions | AAA52569 CAA41399 EAW90226 EAW90227 P14672 AK300899 BAG62537 AK313372 BAG36171 AL521328 BC034387 AAH34387 BC069615 AAH69615 BC069621 AAH69621 BC113592 AAI13593 BC126164 AAI26165 BQ775137 CF594356 HQ258267 ADR83021 M20747 AAA59189 NM_001042 NP_001033 |
Function | Insulin-regulated facilitative glucose transporter. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endomembrane system {ECO:0000269|PubMed:8300557}; Multi-pass membrane protein {ECO:0000269|PubMed:8300557}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:8300557}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration. |
Tissue Specificity | Skeletal and cardiac muscles; brown and white fat. |
Top Pathways | Insulin signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, AMPK signaling pathway |
Glut4 CRISPR/Cas9 KO Plasmid (h) - sc-400158 from Santa Cruz Biotechnology
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Glut4 HDR Plasmid (h) - sc-400158-HDR from Santa Cruz Biotechnology
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Glut4 Double Nickase Plasmid (h) - sc-400158-NIC from Santa Cruz Biotechnology
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Glut4 Double Nickase Plasmid (h2) - sc-400158-NIC-2 from Santa Cruz Biotechnology
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Glut4 CRISPR Activation Plasmid (h) - sc-400158-ACT from Santa Cruz Biotechnology
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Glut4 CRISPR Activation Plasmid (h2) - sc-400158-ACT-2 from Santa Cruz Biotechnology
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Glut4 Lentiviral Activation Particles (h) - sc-400158-LAC from Santa Cruz Biotechnology
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Glut4 Lentiviral Activation Particles (h2) - sc-400158-LAC-2 from Santa Cruz Biotechnology
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Glut4 siRNA (h) - sc-41220 from Santa Cruz Biotechnology
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Glut4 shRNA Plasmid (h) - sc-41220-SH from Santa Cruz Biotechnology
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Glut4 shRNA (h) Lentiviral Particles - sc-41220-V from Santa Cruz Biotechnology
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Glut4 RNAi - H00006517-R01 from Novus Biologicals
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MISSION® esiRNA - EHU154001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1887 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1887 from Sigma-Aldrich
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SLC2A4 siRNA (Human) - CRH4411 from Cohesion Biosciences
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SLC2A4 - MBS8204965 from MyBioSource
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shRNA set against Human SLC2A4 (NM_001042.2) - SHH410276 from Creative biogene
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shRNA set against Human SLC2A4(NM_001042.2) - SHL005026 from Creative biogene
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Human SLC2A4 siRNA - orb264913 from Biorbyt
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SLC2A4 shRNA Plasmid (Human) - CHH4411 from Cohesion Biosciences
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SLC2A4 miRNA 3'UTR clone - MiUTR1H-09517 from Creative biogene
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